Increased brain edema in aqp4-null mice in an experimental model of subarachnoid hemorrhage.

Neuroscience
M J TaitM C Papadopoulos

Abstract

We investigated the role of the glial water channel protein aquaporin-4 in brain edema in a mouse model of subarachnoid hemorrhage in which 30 microl of blood was injected into the basal cisterns. Brain water content, intracranial pressure and neurological score were compared in wildtype and aquaporin-4 null mice. We also measured blood-brain barrier permeability, and the osmotic permeability of the glia limitans, one of the routes of edema elimination. Wildtype and aquaporin-4 null mice had comparable baseline brain water content, intracranial pressure and neurological score. At 6 h after blood injection, aquaporin-4 null mice developed more brain swelling than wildtype mice. Brain water content increased by 1.5+/-0.1% vs. 0.5+/-0.2% (Mean+/-Standard Error, P<0.0005) and intracranial pressure by 36+/-5 vs. 21+/-3 mm Hg (P<0.05) above pre-injection baseline, and neurological score was worse at 18.0 vs. 24.5 (median, P<0.05), respectively. Although subarachnoid hemorrhage produced comparable increases in blood-brain barrier permeability in wildtype and aquaporin-4 null mice, aquaporin-4 null mice had a twofold reduction in glia limitans osmotic permeability. We conclude that aquaporin-4 null mice manifest increased brain edema f...Continue Reading

References

Sep 1, 1979·Stroke; a Journal of Cerebral Circulation·K J BarryB M Stein
Jan 1, 1977·Journal of Neurosurgery·H J ReulenI Klatzo
Jan 1, 1985·Stroke; a Journal of Cerebral Circulation·R A SolomonS Chien
Jul 1, 1995·Stroke; a Journal of Cerebral Circulation·J A VeelkenJ Jakubowski
May 4, 2002·Stroke; a Journal of Cerebral Circulation·Jan ClaassenStephan A Mayer
Jul 4, 2002·The Journal of Physiology·Peter AgreSøren Nielsen
Jul 16, 2002·Neurological Research·Augusto ParraDavid S Warner
Jun 23, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Marios C PapadopoulosA S Verkman
Feb 8, 2005·The Journal of Biological Chemistry·Marios C Papadopoulos, A S Verkman
Mar 23, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Orin BlochA S Verkman
Dec 7, 2007·Trends in Neurosciences·Matthew J TaitMarios C Papadopoulos

❮ Previous
Next ❯

Citations

Jul 14, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Aristotelis S FilippidisHarold L Rekate
May 10, 2011·Acta Pharmacologica Sinica·Alan S VerkmanLukmanee Tradtrantip
Jan 2, 2013·Proceedings of the National Academy of Sciences of the United States of America·Dominique PromeneurPeter Agre
Nov 9, 2010·Cerebrospinal Fluid Research·Anders D SkjoldingMarianne Juhler
Mar 15, 2014·Nature Reviews. Drug Discovery·Alan S VerkmanMarios C Papadopoulos
Jul 1, 2014·Laboratory Investigation; a Journal of Technical Methods and Pathology·Heling ChuQiang Dong
Mar 14, 2013·Nature Reviews. Neuroscience·Marios C Papadopoulos, Alan S Verkman
Jul 31, 2013·Translational Stroke Research·Mutsumi FujiiJohn H Zhang
May 21, 2014·British Journal of Neurosurgery·Carl MuroiMichihiro Fujiwara
Aug 7, 2012·The Journal of Toxicological Sciences·Megumi YamamotoKomyo Eto
Aug 17, 2016·International Journal of Molecular Sciences·Heling ChuQiang Dong
Oct 1, 2016·International Journal of Molecular Sciences·Guanghui Tang, Guo-Yuan Yang
Jan 16, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Lorenz HirtJerome Badaut
Sep 30, 2016·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Nefize TuranGustavo Pradilla
Aug 1, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Andrew M FukudaJerome Badaut
Jul 22, 2016·International Journal of Molecular Sciences·Lauren E PrevichYuchuan Ding
Apr 16, 2011·Stroke; a Journal of Cerebral Circulation·Raimund HelbokJan Claassen
Sep 13, 2018·American Journal of Physiology. Cell Physiology·Ali E SifatThomas J Abbruscato
Apr 12, 2019·Journal of the American Heart Association·Kanako MatsumuraDevin W McBride
Oct 31, 2019·Brain : a Journal of Neurology·Cameron J HertingDolores Hambardzumyan
Mar 9, 2020·Metabolic Brain Disease·Ali SepehrinezhadRoger Williams
Aug 13, 2020·Molecular Neurobiology·Gabriela-Camelia RosuPirici Daniel
Jun 9, 2016·Metabolic Brain Disease·Chantal BémeurChristopher F Rose
May 13, 2020·Neural Regeneration Research·Xiaowei WangJason H Huang
May 19, 2019·International Journal of Molecular Sciences·Tetsuya Takahashi, Takayoshi Shimohata
Dec 21, 2016·Neurocritical Care·Erik G HaymanJ Marc Simard
Oct 2, 2020·Cells·Sven Olaf RohrMarkus Kipp
Mar 8, 2021·Experimental Neurology·Caihong JiAnwen Shao
Jun 24, 2021·Journal of Neurochemistry·Jiru ZhouHua Feng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Barrel cortex

Here is the latest research on barrel cortex, a region of somatosensory and motor corticies in the brain, which are used by animals that rely on whiskers for world exploration.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Related Papers

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
M C Papadopoulos, A S Verkman
Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
Orin BlochA S Verkman
© 2021 Meta ULC. All rights reserved