Increased brain histamine H3 receptor expression during hibernation in golden-mantled ground squirrels

BMC Neuroscience
T SallmenPertti Panula

Abstract

Hibernation is a state of extremely reduced physiological functions and a deep depression of CNS activity. We have previously shown that the histamine levels increase in the brain during hibernation, as does the ratio between histamine and its first metabolite, suggesting increased histamine turnover during this state. The inhibitory histamine H3 receptor has both auto- and heteroreceptor function, rendering it the most likely histamine receptor to be involved in regulating the activity of histamine as well as other neurotransmitters during hibernation. In view of accumulating evidence that there is a global depression of transcription and translation during hibernation, of all but a few proteins that are important for this physiological condition, we reasoned that an increase in histamine H3 receptor expression would clearly indicate an important hibernation-related function for the receptor. In this study we show, using in situ hybridization, that histamine H3 receptor mRNA increases in the cortex, caudate nucleus and putamen during hibernation, an increase that is accompanied by elevated receptor binding in the cerebral cortex, globus pallidus and substantia nigra. These results indicate that there is a hibernation-related i...Continue Reading

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Citations

Oct 19, 2016·Molecular Pharmacology·Gustavo Nieto-AlamillaJosé-Antonio Arias-Montaño
Feb 26, 2019·British Journal of Pharmacology·Pertti Panula
Jul 16, 2008·Physiological Reviews·Helmut L HaasOliver Selbach
Jun 19, 2015·Pharmacological Reviews·Pertti PanulaHelmut L Haas
Jun 25, 2005·The Journal of Pharmacology and Experimental Therapeutics·Marcello CanonacoRosa Maria Facciolo
Nov 15, 2011·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Gregory L Florant, Jessica E Healy

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