Hibernation is a state of extremely reduced physiological functions and a deep depression of CNS activity. We have previously shown that the histamine levels increase in the brain during hibernation, as does the ratio between histamine and its first metabolite, suggesting increased histamine turnover during this state. The inhibitory histamine H3 receptor has both auto- and heteroreceptor function, rendering it the most likely histamine receptor to be involved in regulating the activity of histamine as well as other neurotransmitters during hibernation. In view of accumulating evidence that there is a global depression of transcription and translation during hibernation, of all but a few proteins that are important for this physiological condition, we reasoned that an increase in histamine H3 receptor expression would clearly indicate an important hibernation-related function for the receptor. In this study we show, using in situ hybridization, that histamine H3 receptor mRNA increases in the cortex, caudate nucleus and putamen during hibernation, an increase that is accompanied by elevated receptor binding in the cerebral cortex, globus pallidus and substantia nigra. These results indicate that there is a hibernation-related i...Continue Reading
Multiple neurotransmitters in the tuberomammillary nucleus: comparison of rat, mouse, and guinea pig
High affinity histamine binding site is the H3 receptor: characterization and autoradiographic localization in rat brain.
Regional changes in central monoamine and metabolite levels during the hibernation cycle in the golden-mantled ground squirrel
The histaminergic system in the guinea pig central nervous system: an immunocytochemical mapping study using an antiserum against histamine
In vivo analysis of dopamine and its metabolites in the caudate nucleus during euthermia and hibernation
Adrenal dopamine-beta-hydroxylase activity in the ground squirrel Citellus citellus--effect of hibernation, arousal, and continuous light
In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.
Histamine H3 receptor activation selectively inhibits dopamine D1 receptor-dependent [3H]GABA release from depolarization-stimulated slices of rat substantia nigra pars reticulata
Daily variation of CNS gene expression in nocturnal vs. diurnal rodents and in the developing rat brain
Histamine and spontaneous motor activity: biphasic changes, receptors involved and participation of the striatal dopamine system
Postnatal expression of H1-receptor mRNA in the rat brain: correlation to L-histidine decarboxylase expression and local upregulation in limbic seizures
Suppression of protein synthesis in brain during hibernation involves inhibition of protein initiation and elongation
The pharmacological and functional characteristics of the serotonin 5-HT(3A) receptor are specifically modified by a 5-HT(3B) receptor subunit.
Histaminergic neurons modulate acetylcholine release in the ventral striatum: role of H1 and H2 histamine receptors
Mechanisms for increased levels of phosphorylation of elongation factor-2 during hibernation in ground squirrels
Differential expression of adipose- and heart-type fatty acid binding proteins in hibernating ground squirrels
Coordinate expression of the PDK4 gene: a means of regulating fuel selection in a hibernating mammal
The translation state of differentially expressed mRNAs in the hibernating 13-lined ground squirrel (Spermophilus tridecemlineatus)
Elevated arylalkylamine-N-acetyltransferase (AA-NAT) gene expression in medial habenular and suprachiasmatic nuclei of hibernating ground squirrels
The role of histamine 3 receptors in the control of food intake in a seasonal model of obesity: the Siberian hamster.
Central nervous system regulation of mammalian hibernation: implications for metabolic suppression and ischemia tolerance
The histaminergic signaling system exerts a neuroprotective role against neurodegenerative-induced processes in the hamster
Short photoperiod-induced decrease of histamine H3 receptors facilitates activation of hypothalamic neurons in the Siberian hamster.
Histamine H3 receptor and orexin A expression during daily torpor in the Djungarian hamster (Phodopus sungorus).
Seasonal decrease in thermogenesis and increase in vasoconstriction explain seasonal response to N6 -cyclohexyladenosine-induced hibernation in the Arctic ground squirrel (Urocitellus parryii).
Effects of histamine H3 receptor ligands on the rewarding, stimulant and motor-impairing effects of ethanol in DBA/2J mice
Neuroprotective effects of hibernation-regulating substances against low-temperature-induced cell death in cultured hamster hippocampal neurons
Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.