PMID: 3763049Aug 29, 1986Paper

Increased brain levels of cholecystokinin octapeptide after kainic acid-induced seizures in the rat

Neuroscience Letters
D K MeyerG Sperk

Abstract

Pronounced changes in the content of cholecystokinin octapeptide (CCK-8) have been found after limbic seizures induced by i.p. injection of kainic acid. Three hours after injection of the toxin a significant decrease in CCK-8 was observed in the frontal cortex and amygdala/pyriform cortex reflecting an increased release during acute seizures. A persistent decrease in the content of the peptide in the amygdala/pyriform cortex suggests destruction of the respective neurons. In the substantia nigra and in the striatum and, more moderately, in the hippocampus and frontal cortex increases in CCK-8 were observed 10 days after injection of kainic acid suggesting an increased synthesis or decreased release of the peptide in these brain areas subsequently to the acute seizures.

Citations

Jan 1, 1996·Brain Research. Molecular Brain Research·L X ZhangR M Post
Jan 1, 1989·Neurochemistry International·K TakedaT Kato
Jan 1, 1994·Progress in Neurobiology·G Sperk
Jan 1, 1990·The European Journal of Neuroscience·Josef MarksteinerGünther Sperk
Aug 1, 1994·The European Journal of Neuroscience·S D CrollH Nawa
Jan 1, 1991·Annals of the New York Academy of Sciences·A SariaR Bellmann

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