Increased brain tumor resection using fluorescence image guidance in a preclinical model

Lasers in Surgery and Medicine
Arjen BogaardsBrian C Wilson

Abstract

Fluorescence image-guided brain tumor resection is thought to assist neurosurgeons by visualizing those tumor margins that merge imperceptibly into normal brain tissue and, hence, are difficult to identify. We compared resection completeness and residual tumor, determined by histopathology, after white light resection (WLR) using an operating microscope versus additional fluorescence guided resection (FGR). We employed an intracranial VX2 tumor in a preclinical rabbit model and a fluorescence imaging/spectroscopy system, exciting and detecting the fluorescence of protoporphyrin IX (PpIX) induced endogenously by administering 5-aminolevulinic acid (ALA) at 4 hours before surgery. Using FGR in addition to WLR significantly increased resection completeness by a factor 1.4 from 68+/-38 to 98+/-3.5%, and decreased the amount of residual tumor post-resection by a factor 16 from 32+/-38 to 2.0+/-3.5% of the initial tumor volume. Additional FGR increased completeness of resection and enabled more consistent resections between cases.

References

Sep 1, 1996·Journal of Photochemistry and Photobiology. B, Biology·H J SterenborgM Motamedi
Feb 1, 1997·Photochemistry and Photobiology·Q PengJ M Nesland
Jul 15, 1998·Journal of Clinical Laser Medicine & Surgery·L Lilge, B C Wilson
Jan 14, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·N KawaiR F Keep
Feb 19, 2002·Current Opinion in Biotechnology·Warren C W ChanShuming Nie
Sep 18, 2002·Proceedings of the National Academy of Sciences of the United States of America·Maria E AkermanErkki Ruoslahti
Oct 31, 2002·Journal of Neurosurgery·Bernhard OlzowyWalter Stummer
Nov 28, 2002·International Journal of Cancer. Journal International Du Cancer·Johan MoanQian Peng
Dec 21, 2002·Brain Research·S R EnnisR F Keep
Nov 5, 2003·Nature Biotechnology·Warren R ZipfelWatt W Webb

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Citations

Apr 1, 2010·Chemical Reviews·Jonathan P CelliTayyaba Hasan
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Vasilis Ntziachristos
Oct 20, 2012·Theranostics·Yumiao Zhang, Jonathan F Lovell
Apr 22, 2011·Annals of Surgical Oncology·George ThemelisVasilis Ntziachristos
Jul 2, 2009·Journal of Biomedical Optics·Pilar Beatriz Garcia-AllendeBrian W Pogue
Jan 5, 2011·Journal of Biomedical Optics·Vasilis NtziachristosGooitzen M van Dam
Feb 25, 2009·Acta neurochirurgica·Sven Rainer KantelhardtAlf Giese
Mar 2, 2016·Neurosurgical Focus·Pablo A ValdésAlexandra Golby
Apr 17, 2008·Lasers in Surgery and Medicine·Sven Rainer KantelhardtAlf Giese
Sep 28, 2010·Journal of Surgical Oncology·Greg M ThurberRalph Weissleder
Feb 5, 2013·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Xinhui SuZhen Cheng
Oct 6, 2012·Lasers in Surgery and Medicine·Alex J WalshAnita Mahadevan-Jansen
Jan 16, 2010·Lasers in Surgery and Medicine·Neda Haj-HosseiniKarin Wårdell
Jul 31, 2010·IEEE Journal of Selected Topics in Quantum Electronics : a Publication of the IEEE Lasers and Electro-optics Society·Brian W PogueKeith D Paulsen
Jun 12, 2008·Optics Express·N I SmithS Kawata
Jun 12, 2008·Optics Express·Severine PhilippeHoracio Soto-Ortiz
Jun 12, 2008·Optics Express·Siavash YazdanfarRobert J Filkins
Jun 12, 2008·Optics Express·Francisco J RodriguezMartti Kauranen
Jun 12, 2008·Optics Express·Tomohiko Asatsuma, Toshihiko Baba
Feb 6, 2007·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Reinhard SailerHerbert Schneckenburger
May 6, 2005·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Arjen BogaardsBrian C Wilson
Apr 27, 2012·Journal of Ultrasound in Medicine : Official Journal of the American Institute of Ultrasound in Medicine·Jia WangYun You Duan

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