PMID: 6107500Oct 18, 1980Paper

Increased breast-cancer recurrence rate after adjuvant therapy with levamisole. A preliminary report. Executive Committee of the Danish Breast Cancer Cooperative Group

Lancet

Abstract

After total mastectomy with partial axillary-lymph-node biopsy, patients with breast carcinomas with histologically positive lymph-nodes but without distant metastasis (N+, Mo) were allocated at random to receive either radiotherapy alone (384 patients) or radiotherapy plus levamisole 2.5 mg/kg/day for two consecutive days each week for 48 weeks (336 patients). At 1 year the levamisole-treated patients had a significantly higher recurrence rate than the radiotherapy-only group. They also had an unacceptably high incidence of side-effects, especially patients aged over 50. The frequency of levamisole-induced agranulocytosis was 3.6% and leucopenia 15-20%. These preliminary results suggest that adjuvant therapy with levamisole should not be used in patients with N+, Mo breast carcinoma.

References

Jan 31, 1976·Lancet·A F RojasA J Olivari
Aug 1, 1975·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A Mantovani, F Spreafico
Apr 1, 1989·British Journal of Anaesthesia·T E Oh, J M Horton

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Citations

Mar 15, 1984·Klinische Wochenschrift·J Drews
Feb 15, 1984·Klinische Wochenschrift·G A Nagel
Mar 1, 1988·European Journal of Cancer & Clinical Oncology·C KambyK Zedeler

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