Increased burden of comorbidities and risk of cardiovascular death in atrial fibrillation patients in Europe over ten years: A comparison between EORP-AF pilot and EHS-AF registries

European Journal of Internal Medicine
Marco ProiettiEuro Heart Survey on AF Investigators

Abstract

In 2002, the European Society of Cardiology conducted the Euro Heart Survey (EHS), while in 2014concluded 1-year follow-up of the EURObservational Research Programme AF (EORP-AF) Pilot Registry. We analysed differences in clinical profiles, therapeutic approaches and outcomes between these two cohorts after propensity score matching (PSM). After PSM, 5206 patients were analysed. In EORP-AF there were more elderly patients than EHS (p < .001). EORP-AF patients were more burdened with cardiovascular (CV) and non-CV comorbidities, with a higher proportion of patients with high thromboembolic risk. EORP-AF patients used more oral-anticoagulant (OAC) (p < .001). At 1-year follow-up EORP-AF patients had lower risk for thromboembolic and CV events, readmission for AF and other CV reasons (all p < .001), showing conversely a higher risk for CV death (p = .015). Kaplan-Meier curves showed that EORP-AF patients had higher risk for CV death (p < .0001) and all-cause death (p = .0019). Cox regression confirmed that EORP-AF patients were at higher risk for CV death (p = .021). We found significant changes in AF epidemiology over a decade in Europe, with older patients, more burdened with comorbidities. A greater use of OAC was found. Despit...Continue Reading

Citations

Nov 15, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christian Torp-PedersenUNKNOWN External Reviewers
Oct 3, 2020·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Marco ProiettiUNKNOWN ESC-EORP Atrial Fibrillation General Long-Term Registry Investigators Group
Jun 27, 2019·Journal of the American Heart Association·Yan-Guang LiLaurent Fauchier
Mar 25, 2019·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Giuseppe BorianiUNKNOWN EORP-AF Long-Term General Registry Investigators
Dec 29, 2020·JACC. Cardiovascular Interventions·Giuseppe Tarantini, UNKNOWN Amplatzer Amulet Global Observational Study Investigators
Jan 26, 2021·Expert Opinion on Pharmacotherapy·Agnieszka KotalczykGregory Y H Lip
Jan 23, 2021·European Journal of Clinical Investigation·Marco ProiettiGregory Y H Lip
Oct 29, 2020·Nature Reviews. Cardiology·Agnieszka KotalczykGregory Y H Lip
Jul 26, 2021·Experimental Gerontology·Marco ProiettiUNKNOWN FANTASIIA Study Investigators
Aug 2, 2021·European Heart Journal·Giulio Francesco RomitiUNKNOWN AF-COMET International Collaborative Group
Aug 20, 2021·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Laurent FauchierA John Camm

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