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Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice

Experimental Gerontology

Jul 26, 2019

Mi-Jung KimShinichi Someya

Abstract

Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator ...read more

Mentioned in this Paper

Study
DNA, Mitochondrial
Neurons
Nerve Degeneration
Gene Deletion
Mitochondria
Left Cochlea
Aging
Mitochondrial DNA Deletion
Labyrinth
2
4
Paper Details
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Increased burden of mitochondrial DNA deletions and point mutations in early-onset age-related hearing loss in mitochondrial mutator mice

Experimental Gerontology

Jul 26, 2019

Mi-Jung KimShinichi Someya

PMID: 31344454

DOI: 10.1016/j.exger.2019.110675

Abstract

Mitochondrial DNA (mtDNA) mutations are thought to have a causal role in a variety of age-related neurodegenerative diseases, including age-related hearing loss (AHL). In the current study, we investigated the roles of mtDNA deletions and point mutations in AHL in mitochondrial mutator ...read more

Mentioned in this Paper

Study
DNA, Mitochondrial
Neurons
Nerve Degeneration
Gene Deletion
Mitochondria
Left Cochlea
Aging
Mitochondrial DNA Deletion
Labyrinth
2
4

Similar Papers Found In These Feeds

Acute Hemorrhagic Leukoencephalitis

Acute hemorrhagic leukoencephalitis is a rare form of acute disseminated encephalomyelitis characterized by acute inflammation in the brain and spinal cord that causes demyelination and bleeding. It is often fatal, although treatment with immunosuppressives and plasma exchange can be helpful. Find the latest research on acute hemorrhagic leukoencephalitis here.

Cell Aging

This feed focuses on cellular aging with emphasis on the mitochondria, autophagy, and metabolic processes associated with aging and longevity. Here is the latest research on cell aging.

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Molecular mechanism of age-related hearing loss: toward its prevention

Nihon Jibiinkoka Gakkai kaihoJune 13, 2009
Tatsuya Yamasoba
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