Increased burst size in multiply infected cells can alter basic virus dynamics.

Biology Direct
Kara W CummingsD Wodarz

Abstract

The dynamics of viral infections have been studied extensively in a variety of settings, both experimentally and with mathematical models. The majority of mathematical models assumes that only one virus can infect a given cell at a time. It is, however, clear that especially in the context of high viral load, cells can become infected with multiple copies of a virus, a process called coinfection. This has been best demonstrated experimentally for human immunodeficiency virus (HIV), although it is thought to be equally relevant for a number of other viral infections. In a previously explored mathematical model, the viral output from an infected cell does not depend on the number of viruses that reside in the cell, i.e. viral replication is limited by cellular rather than viral factors. In this case, basic virus dynamics properties are not altered by coinfection. Here, we explore the alternative assumption that multiply infected cells are characterized by an increased burst size and find that this can fundamentally alter model predictions. Under this scenario, establishment of infection may not be solely determined by the basic reproductive ratio of the virus, but can depend on the initial virus load. Upon infection, the virus po...Continue Reading

References

May 16, 1998·Journal of Theoretical Biology·R J De Boer, A S Perelson
Jan 20, 1999·Journal of Theoretical Biology·D WodarzM A Nowak
Sep 28, 1999·The Journal of Experimental Medicine·S J LittleD V Havlir
Mar 22, 2002·Nature Reviews. Immunology·Alan S Perelson
Jul 12, 2002·Nature·Andreas JungAndreas Meyerhans
Jan 7, 2004·Proceedings of the National Academy of Sciences of the United States of America·Que DangWei-Shau Hu
Mar 11, 2004·Proceedings of the National Academy of Sciences of the United States of America·David N LevyGeorge M Shaw
Apr 1, 2004·Current HIV Research·Karine LevesqueEric A Cohen
Jul 29, 2004·Journal of Virology·Narendra M Dixit, Alan S Perelson
Nov 30, 2004·Science·Sebastian BonhoefferChristos J Petropoulos
Jun 2, 2005·Proceedings of the National Academy of Sciences of the United States of America·Narendra M Dixit, Alan S Perelson
Aug 19, 2005·Retrovirology·Micha NetheAntoinette C van der Kuyl
Jul 20, 2006·Journal of the Royal Society, Interface·Christophe Fraser
Oct 20, 2006·Trends in Microbiology·Roger D KouyosSebastian Bonhoeffer
Mar 6, 2007·Trends in Ecology & Evolution·Roger D KouyosSebastian Bonhoeffer
Jul 11, 2008·Retrovirology·Huub C GelderblomDavid N Levy
Jun 22, 2011·Proceedings of the National Academy of Sciences of the United States of America·Lina JosefssonSarah E Palmer
Aug 24, 2011·Computational and Mathematical Methods in Medicine·Jing LiRobert J Smith

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Citations

Jan 30, 2013·Mathematical Biosciences·Natalia L Komarova, Dominik Wodarz
Jul 3, 2013·Scientific Reports·Natalia L KomarovaDominik Wodarz
Mar 15, 2015·Mathematical Biosciences·Dustin Phan, Dominik Wodarz
Apr 25, 2015·Journal of Theoretical Biology·Ani AsatryanNatalia L Komarova
Jun 7, 2019·Diseases of Aquatic Organisms·Juliette DoumayrouAndrew R Wargo
Feb 23, 2019·Evolution Letters·Dominik WodarzNatalia L Komarova
May 21, 2020·Viruses·Veronika BernhauerováMarco Vignuzzi

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