Increased c-fos expression in the brain during experimental murine cerebral malaria: possible association with neurologic complications

The Journal of Infectious Diseases
N MaN H Hunt

Abstract

Cerebral expression of c-fos protein was studied by immunocytochemistry in murine cerebral malaria (CM) and malaria without cerebral involvement (non-CM). c-fos expression, low in the brains of uninfected mice, increased in frequency, intensity, and distribution during the course of fatal CM (e.g., a 70-fold increase on day 7 after inoculation). These changes paralleled the timing and degree of the neurologic complications and histopathologic changes. Only a slight increase in c-fos expression was detectable in non-CM mice on day 7 after inoculation. Dexamethasone treatment (days 0 and 1 after inoculation) of the CM mice largely prevented the increased cerebral c-fos expression, histopathologic changes, cerebral complications, and death. Increased c-fos expression may indicate the specific neuronal pathways activated by the immunopathologic process of fatal murine CM and could be associated with the behavioral changes and neurologic complications in this model.

Citations

Oct 14, 2008·Malaria Journal·Peter LacknerErich Schmutzhard
Oct 8, 2011·PloS One·Peter LacknerErich Schmutzhard
Apr 8, 2006·Neuropathology and Applied Neurobiology·P LacknerE Schmutzhard
Feb 15, 2019·Frontiers in Immunology·Teresa F Pais, Carlos Penha-Gonçalves
Jul 23, 2021·Scientific Reports·Luciana Pereira de SousaCláudio Tadeu Daniel-Ribeiro

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