PMID: 8944819Nov 1, 1996Paper

Increased cardiac fatty acid uptake with dobutamine infusion in swine is accompanied by a decrease in malonyl CoA levels

Cardiovascular Research
J L HallWilliam C Stanley

Abstract

Malonyl CoA is an important regulator of fatty acid oxidation in the heart secondary to its ability to inhibit carnitine palmitoyltransferase 1 (CPT 1). Malonyl CoA is produced from acetyl CoA in a reaction catalyzed by acetyl CoA carboxylase (ACC). In this study we determined if alterations in malonyl CoA regulation of fatty acid metabolism are involved in the increase in energy transduction seen following an increase in cardiac work. Anesthetized, open-chest, domestic swine were subjected to a 30 min control period followed by a 30 min treatment period with either dobutamine (15 micrograms.kg-1. min-1 i.v.) (n = 6) or saline (n = 6). Heart rate, left ventricular peak dp/dt, and MVO2, were significantly increased in the dobutamine group compared to the saline group during the treatment period. Free fatty acid and glucose uptake were increased 210 and 248%, respectively, in the dobutamine group during the treatment period. Malonyl CoA content was decreased by 55% (from 0.40 +/- 0.05 to 0.18 +/- 0.12 nmol/g wet wt; P < 0.05) with dobutamine treatment, but was not affected by saline treatment. ACC activity was not significantly different between groups (0.31 +/- 0.02 vs. 0.30 +/- 0.04 nmol. min-1. mg protein-1, respectively). The...Continue Reading

Citations

Dec 1, 2006·Cardiovascular Drugs and Therapy·Gary D Lopaschuk, William C Stanley
Feb 4, 2011·Cardiovascular Research·Vincenzo LionettiFabio A Recchia
Sep 4, 2014·The Journal of Physiological Sciences : JPS·M DervisevikB Miova
Jun 4, 2004·Biomedical Engineering Online·Jennifer E SalemMarco E Cabrera
May 13, 2006·The Journal of Physiology·Jason R B Dyck, Gary D Lopaschuk
Aug 6, 2010·Journal of Magnetic Resonance·Małgorzata MarjańskaPierre-Gilles Henry
Jul 4, 2012·Molecular and Cellular Endocrinology·Jeevan NagendranJason R B Dyck
Jan 26, 2011·Journal of Molecular and Cellular Cardiology·Lisa C Heather, Kieran Clarke
Oct 10, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ulrich KoellischRolf F Schulte
Sep 21, 2004·Journal of Cardiovascular Pharmacology and Therapeutics·William C Stanley
Oct 16, 2010·Arteriosclerosis, Thrombosis, and Vascular Biology·Neeta AdhikariJennifer L Hall
Apr 12, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kristen L KingWilliam C Stanley
Jul 1, 2005·Physiological Reviews·William C StanleyGary D Lopaschuk
Dec 13, 2005·Coronary Artery Disease·Giuseppe M C RosanoMassimo Fini
Apr 11, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Lufang ZhouWilliam C Stanley
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Vernon W Dolinsky, Jason R B Dyck
Dec 18, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Lufang ZhouWilliam C Stanley
Jan 21, 2010·Physiological Reviews·Gary D LopaschukWilliam C Stanley
Jan 22, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Vijay SharmaJohn H McNeill
Feb 1, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Lufang ZhouMarco E Cabrera
Sep 25, 2004·Canadian Journal of Physiology and Pharmacology·Rodrigo AzueroDuna Penn

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