PMID: 15379418Sep 24, 2004Paper

Increased cardiac troponin I concentration in diabetic ketoacidosis

Journal of Pediatric Endocrinology & Metabolism : JPEM
Mehmet Emre AtabekSelim Kurtoglu

Abstract

To examine the hypothesis that diabetic ketoacidosis may be associated with some degree of induced injury to heart muscle, related either to acidosis or hyperglycemia. Nineteen diabetic patients with acute ketoacidosis and 19 healthy children were enrolled in this study. Cardiac troponin I (cTnI), creatine kinase (CK)-MB and myoglobin levels were analyzed soon after admission and after 24 h. Patients were subdivided into two groups according to blood pH. At the time of admission, the diabetic patients had significantly higher values than the controls for cTnI (0.193+/-0.008 vs 0.176+/-0.006 ng/dl; p <0.001), CK-MB (24.1+/-2.1 vs 22.7+/-1.2 U/l; p = 0.02), and myoglobin (85.5+/-7.4 vs 52.5 +/-8.3 microg/dl; p <0.001). The diabetic patients also had significantly higher values than the controls for CK-MB (24+/-2.1 vs 22.7+/-1.2 U/l; p = 0.02) and for myoglobin (78.5+/-2.5 vs 52.5+/-8.3 microg/dl; p <0.001) at 24 h. cTnI had normalized in patients at 24 h. All parameters were significantly different between patients with pH > or =7.0 and patients with pH <7.0. In addition, serum cTnI levels correlated negatively with blood pH (r = -0.57, p = 0.026) and HCO3- (r = -0.65, p = 0.008) in the patients with diabetic ketoacidosis on admi...Continue Reading

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Citations

Dec 12, 2013·Internal and Emergency Medicine·Gregor LindnerAristomenis Konstantinos Exadaktylos
Jul 25, 2013·The Journal of Emergency Medicine·Rajan AroraNirupama Kannikeswaran
Mar 14, 2019·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ragaa Abd-Elsalam MohamedRadwa Saeed Ibrahim

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