PMID: 9179059Jun 1, 1997Paper

Increased cathepsin D level in the serum of patients with metastatic breast carcinoma detected with a specific pro-cathepsin D immunoassay

Cancer
J P BrouilletH Rochefort

Abstract

An increased cathepsin D (cath-D) level in breast carcinoma cytosol has been proposed as a prognostic parameter. However, no increase had been previously detected in serum when assaying total cath-D concentration. The authors compared 2 radioimmunoassays of total cath-D and pro-cath-D in the serum of 3 groups of patients: those with metastatic breast carcinomas (n = 30), those with nonmetastatic breast carcinomas (n = 24), and healthy women (n = 21). There was a significant increase of total cath-D and pro-cath-D in the serum of 18 of the 30 patients with metastatic breast carcinoma. No increase was observed in any of the patients with nonmetastatic disease compared with healthy women. Moreover, the level of pro-cath-D was often superior to that of total cath-D in the same patients, suggesting that the total cath-D assay in serum underestimates the actual concentration of pro-cath-D. This is not believed to be due to the masking of cath-D with the circulating mannose-6-phosphate/insulin-like growth factor II receptor because the purified receptor did not interfere in the binding of the monoclonal antibodies used in the assay to cath-D. An increased level of cath-D in the serum of breast carcinoma patients is a late event observ...Continue Reading

References

Jan 1, 1992·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H Rochefort
Apr 1, 1990·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P BrouilletH Rochefort
Nov 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·W KiessS P Nissley
Jan 1, 1993·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J P BrouilletH Rochefort

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Citations

Apr 19, 2007·Cancer Research·Zhila Khalkhali-Ellis, Mary J C Hendrix
Apr 27, 2010·The Journal of Biological Chemistry·Congwu ChiTian Xu
Mar 14, 2013·PloS One·Alen FaizJanette K Burgess
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Martin Fusek, Václav Vetvicka
Apr 3, 2007·International Journal of Biological Macromolecules·Sujata Saraswat OhriVaclav Vetvicka
Oct 3, 2003·Journal of Molecular Recognition : JMR·Roberta CastinoCiro Isidoro
Oct 24, 2007·Journal of Neurochemistry·Sangseop KimKyoungho Suk
Feb 4, 2006·Bioorganic & Medicinal Chemistry·Audrey JeanjeanAlain Morère
Jul 28, 2005·Cancer Letters·Emmanuelle Liaudet-CoopmanFrançoise Vignon
Jun 10, 1998·Biochemical and Biophysical Research Communications·I FruitierJ M Piot
May 2, 2001·Gynecologic Oncology·J R BosscherD D Taylor
Jun 22, 2000·The Prostate·V VetvickaM Fusek
Apr 6, 1999·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·H Rochefort, E Liaudet-Coopman
Aug 24, 2005·European Urology·Axel S MerseburgerMarkus A Kuczyk
Oct 16, 2004·Expert Review of Anticancer Therapy·Franco Lumachi, Stefano M M Basso
Feb 3, 2007·Breast Cancer Research and Treatment·Louise M RasmussenAnne E Lykkesfeldt
Sep 12, 2002·Cancer Gene Therapy·Vaclav VetvickaMartin Fusek
Jun 16, 2005·Folia Microbiologica·A VashishtaV Vetvicka
Mar 5, 1999·Breast Cancer Research and Treatment·V StearnsD F Hayes
Jan 1, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Finny MonickarajArup Das

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