Increased caveolin-1 expression associated with prolonged overall survival rate in hepatocellular carcinoma

Pathology
Sheau-Fang YangYao-Tsung Yeh

Abstract

Recent study indicates that the binding of caveolin-1 (CAV1), the essential constituent of caveolae, to endothelial nitric oxide synthase (eNOS) prevents nitric oxide (NO) production in cirrhotic human liver. However, their interplay in hepatocellular carcinoma (HCC) remains undetermined. Paraffin-embedded sections from 73 HCC patients were included in this study. The expression patterns of CAV1 and eNOS determined by immunohistochemistry were correlated with the clinicopathological characteristics and overall survival. Although CAV1 expression did not correlate with any clinicopathological characteristic, increased CAV1 expression was associated with prolonged overall survival (p = 0.021), even when using the multivariate Cox's regression model (OR = 0.25, 95%CI = 0.08-0.72, p = 0.011). eNOS expression was correlated with an increased histological grade (p = 0.002) and intriguingly, the patients had a decreased overall survival when their lesions presented with high eNOS but low CAV1 expression concomitantly (p = 0.003). Meanwhile, the increased CAV1/eNOS merged level determined by immunofluorescence was significantly associated with a decreased histological grade and better overall survival (p = 0.023 and 0.001, respectively)...Continue Reading

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Citations

Jan 19, 2013·Cell Death & Disease·C MeyerS Dooley
Jan 24, 2013·Cell Communication and Signaling : CCS·Christoph MeyerSteven Dooley
Sep 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ye ZhangYun-peng Liu
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Dec 13, 2019·Ultrastructural Pathology·Iuliia TaskaevaIzabella Gogaeva
Jun 1, 2017·World Journal of Surgery·Blanca TorrejónJesús García-Foncillas

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