Increased CD40 ligand gene expression during human renal and murine islet allograft rejection

Transplantation
X X ZhengT B Strom

Abstract

The interaction between CD40 and its ligand CD40L is essential for the development and maintenance of vigorous immunity. We have sought to determine: (i) whether a heightened level of CD40L transcripts is evident during acute allograft rejection and (ii) the kinetics of CD40L gene expression during allograft rejection. By using quantitative reverse transcriptase-assisted polymerase chain reaction techniques, we found that heightened CD40L gene expression is a correlate of acute human renal allograft rejection (P<0.01). In a murine model of MHC-mismatched islet allografts, our results showed that CD40L transcripts were rarely detected at day 2 after transplantation, but were remarkably heightened at day 5 after transplantation. The transcript levels then steadily increased and peaked at the time of rejection. These data suggest that therapy aimed at blocking the CD40 to CD40L interaction should be applied during the immediate posttransplant period.

References

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Citations

Jan 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A S GawecoD H Van Thiel
Aug 17, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Laurent P NicodJean-Claude Pache
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Sep 28, 2000·Current Opinion in Immunology·S J Knechtle
Aug 26, 2006·Nature Clinical Practice. Nephrology·Terry B Strom, Manikkam Suthanthiran
Jun 4, 2002·Transplantation·Miranda M L van RijenJaap Kwekkeboom
Aug 24, 1999·Current Opinion in Nephrology and Hypertension·W W Hancock
Jan 12, 2000·Current Opinion in Nephrology and Hypertension·C van Kooten
Jul 24, 2012·Current Opinion in Critical Care·Thomas FuehnerJens Gottlieb
Oct 19, 2007·Journal of the American Society of Nephrology : JASN·Terry B Strom
Sep 7, 2001·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·A BartlettS Munn
May 31, 2011·Toxicology Letters·Keiyu OshidaYohei Miyamoto
Oct 4, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Adam S R BartlettStephen R Munn
Mar 9, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Masayuki FujinoXiao-Kang Li
May 30, 2001·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·N ShulzhenkoM Gerbase-Delima
Jan 8, 2017·Journal of the American Society of Nephrology : JASN·Madhav C MenonPeter S Heeger
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Matthias KretzlerHermann-Josef Gröne

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