Increased CD80(+) B cells in active multiple sclerosis and reversal by interferon beta-1b therapy

The Journal of Clinical Investigation
K GençA T Reder

Abstract

Costimulatory molecules help determine T cell responses. CD80 (B7-1) and CD86 (B7-2), costimulatory proteins on antigen-presenting cells, bind to CD28 on T cells. When costimulation is coupled with a signal through the T cell receptor (TCR), T cell proliferation and cytokine secretion are induced. However, TCR signaling without CD80/CD86CD28 costimulation causes anergy. During multiple sclerosis (MS) exacerbations, circulating immune cells are activated, Th1 cytokine levels in the blood are elevated, and blood-derived immune cells destroy brain oligodendroglia. In the experimental autoimmune encephalomyelitis model of MS, CD80 on antigen-presenting cells induces Th1 cell responses; CD86 enhances generation of Th2 cells. Variation in CD80 and CD86 expression is likely to influence immune regulation in MS. We demonstrate that the number of circulating CD80(+) lymphocytes is increased significantly during MS exacerbations, but is normal in stable MS. These CD80(+) lymphocytes are predominantly B cells, based on two-color flow cytometry. The number of CD71(+) and HLA-DR+ lymphocytes and monocytes is also increased in active MS. Therapy with IFN beta-1b markedly reduces the number of circulating CD80(+) B cells and increases CD86(+)...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P S Freudenthal, R M Steinman
Jun 8, 1985·Lancet·W A SibleyK Clark
Dec 1, 1988·Journal of Neuroimmunology·M L CuznerM N Woodroofe
Nov 1, 1980·Neurology·R M Bashir, J N Whitaker
Aug 1, 1984·Annals of Neurology·A T RederB G Arnason
Jun 1, 1994·European Journal of Immunology·O RottE Cash
Aug 26, 1994·Science·B K FinckD Wofsy
Jul 1, 1994·Immunology Today·C H JuneC B Thompson
Dec 1, 1994·European Journal of Immunology·K WilliamsJ P Antel
Mar 1, 1995·Journal of Neuropathology and Experimental Neurology·R De SimoneF Aloisi
Jan 1, 1994·Annals of Neurology·H S Panitch
Jun 10, 1994·Science·G LombardiR Lechler
Sep 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J SchiffenbauerJ M Soos
Jul 1, 1996·The Journal of Experimental Medicine·R H Schwartz

❮ Previous
Next ❯

Citations

Nov 19, 2004·Journal of Neurology·Hans-Peter HartungYannis Zoukos
May 10, 2007·Current Neurology and Neuroscience Reports·Eric C Klawiter, Anne H Cross
Oct 26, 2007·Immunologic Research·Sangjin OhHorea Rus
Apr 24, 2013·Drugs·Rehiana AliPaolo Antonio Muraro
Nov 12, 2003·The Journal of Allergy and Clinical Immunology·Tanuja Chitnis, Samia J Khoury
Feb 21, 2004·Journal of Neuroimmunology·Suzy M TeutschGraeme J Stewart
Sep 3, 2013·Mutation Research·Maria MilenkovaInmaculada Domínguez
Oct 9, 2007·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vissia Viglietta, Samia J Khoury
Dec 8, 2000·Journal of Neuroimmunology·A H CrossJ Lyons
Apr 2, 2003·Journal of Neuroimmunology·Paul GniadekFrauke Zipp
Mar 1, 2000·Journal of Neuroimmunology·A Bar-OrD A Hafler
Jan 13, 2000·Current Opinion in Immunology·D E AndersonD A Hafler
Nov 17, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M GiorelliM Trojano
May 30, 2002·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Xuan FengAnthony T Reder
Jul 16, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Dannie E M HallalLeonilda M B Santos
Sep 15, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Darren P BakerGudarz Davar
Mar 17, 2012·Clinical Neuropharmacology·Dimitrios K KitsosKonstantine I Voumvourakis
Dec 22, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·R Hohlfeld
Nov 11, 2003·Clinical and Diagnostic Laboratory Immunology·S G RhodesH M Vordermeier
Mar 13, 2001·Annual Review of Immunology·B Salomon, J A Bluestone
Nov 19, 2011·Multiple Sclerosis International·Sara Ireland, Nancy Monson
Mar 5, 2011·Molecular Medicine·Giuseppe FaracoAlberto Chiarugi
Nov 24, 2007·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·A Créange
Dec 15, 2010·Drugs·Aaron BosterMichael K Racke
Feb 26, 2010·Annals of Indian Academy of Neurology·Kathleen Hawker
Jul 10, 2003·Lancet Neurology·Ralf GoldKlaus V Toyka
Mar 31, 2012·Journal of Neuroimmunology·Robert P LisakAmit Bar-Or
May 5, 1999·Journal of Neuroimmunology·A WindhagenF Heidenreich
Jun 30, 2001·Journal of Neuroimmunology·K MakhloufS J Khoury
Jun 17, 1998·Journal of Neuroimmunology·F SellebjergL P Ryder
Dec 8, 2000·Journal of Neuroimmunology·Z LiuR A Rudick
Jan 5, 2013·Leukemia & Lymphoma·Gerardo FerrerEmili Montserrat
Jan 1, 2007·Expert Review of Clinical Immunology·Claudia J CalderAmit Bar-Or
Sep 1, 2008·Expert Review of Clinical Immunology·Dirk Reske, Walter F Haupt
Aug 13, 2013·Expert Opinion on Biological Therapy·Alexei ShimanovskyConstantin A Dasanu

❮ Previous
Next ❯

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