Increased cerebellar vermis white-matter volume in men with schizophrenia

Journal of Psychiatric Research
Kwang-Hyuk LeePeter W R Woodruff

Abstract

We aimed to investigate cerebellar structural abnormalities and their functional significance in patients with schizophrenia. Forty right-handed men with schizophrenia and 40 sex, age and handedness matched controls underwent a volumetric magnetic resonance scan with 1 mm3 isotropic spatial resolution. Cerebellar grey- and white-matter volumes were analysed using voxel-based morphometry. Patients with schizophrenia completed a battery of neuropsychological tests assessing sustained attention (continuous performance test), memory (Hopkins memory test) and executive function (verbal fluency and Wisconsin card sorting tests). Patients with schizophrenia exhibited significantly increased cerebellar vermis white-matter volume compared with controls. By contrast, total cerebellar volume, and grey- and white-matter volumes of cerebellar hemispheres were not significantly different between groups. Increased vermis white-matter volume in patients was associated with poor verbal fluency performance. We concluded that increased white-matter in the cerebellar vermis, possibly suggesting anomalous connectivity, may be associated with verbal executive dysfunction in men with chronic schizophrenia.

References

Mar 15, 1991·Biological Psychiatry·H A NasrallahJ A Coffman
Apr 1, 1995·Neuropsychologia·P J SnyderJ A Lieberman
Jan 1, 1995·Schizophrenia Bulletin·P Martin, M Albers
Mar 1, 1993·Biological Psychiatry·A RossiM Casacchia
Jan 1, 1997·The Journal of Nervous and Mental Disease·L J SeidmanS M Goldfinger
Dec 16, 1997·The American Journal of Psychiatry·L K JacobsenJ L Rapoport
May 13, 1998·Brain : a Journal of Neurology·J D Schmahmann, J C Sherman
Apr 2, 1999·Journal of Child Psychology and Psychiatry, and Allied Disciplines·P A Filipek
Mar 30, 2000·The American Journal of Psychiatry·J J KimR D Hichwa
Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Jun 23, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·M G LeggioM Molinari
Sep 15, 2000·Archives of General Psychiatry·E V SullivanA Pfefferbaum
Feb 13, 2001·Biological Psychiatry·T IchimiyaY Sudo
Apr 5, 2001·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S MacPherson, S Della Sala
Jun 1, 2001·The American Journal of Psychiatry·R T LoeberD A Yurgelun-Todd
Aug 25, 2001·Annual Review of Neuroscience·F R Robinson, A F Fuchs
Apr 17, 2002·Schizophrenia Research·Gaku OkugawaIngrid Agartz
Aug 10, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·W GerschlagerJ C Rothwell
Dec 31, 2002·The American Journal of Psychiatry·Audrey KellerJudith L Rapoport
Mar 5, 2003·Biological Psychiatry·Philip R SzeszkoRobert M Bilder
Jul 10, 2003·Neuropsychologia·Birgit GottwaldHubertus Maximilian Mehdorn
Jul 24, 2003·Brain : a Journal of Neurology·Maja SteinlinFranz Kaufmann
Sep 30, 2003·The American Journal of Psychiatry·Philip R SzeszkoRobert M Bilder
Jan 20, 2004·Journal of Chemical Neuroanatomy·Jan Voogd
Mar 30, 2004·The Journal of Physiology·Zafiris J DaskalakisRobert Chen
Aug 5, 2004·Neuropsychobiology·Gaku OkugawaToshihiko Kinoshita
Aug 18, 2004·Psychiatry Research·Christian C JoyalHannu J Aronen
Aug 27, 2004·Schizophrenia Research·Elena AntonovaVeena Kumari
Sep 15, 2004·Biological Psychiatry·Timothea ToulopoulouRobin M Murray
Sep 21, 2004·The Journal of Neuropsychiatry and Clinical Neurosciences·Jeremy D Schmahmann
Oct 7, 2004·The American Journal of Psychiatry·Donna J LangWilliam G Honer
Nov 19, 2004·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·K S PaulusI Aiello
Apr 27, 2005·NeuroImage·Dominic E JobStephen M Lawrie
May 11, 2005·Neuroscience Letters·Stefanie RichterDagmar Timmann

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Citations

Jun 15, 2012·Brain Structure & Function·Kaan YucelGlenda M Macqueen
Apr 18, 2009·Cognitive and Behavioral Neurology : Official Journal of the Society for Behavioral and Cognitive Neurology·William D S KillgoreDeborah A Yurgelun-Todd
Aug 10, 2011·Journal of Psychiatric Research·Leonardo BaldaçaraRodrigo A Bressan
Sep 8, 2010·Schizophrenia Research·Asli Demirtas-TatlidedeAlvaro Pascual-Leone
Apr 4, 2007·Journal of Psychiatric Research·Maurice M Ohayon, Alan F Schatzberg
Oct 21, 2009·Bipolar Disorders·Fay Y WomerHilary P Blumberg
Nov 8, 2014·NeuroImage. Clinical·Chiara NosartiMatthew P G Allin
Jun 12, 2013·Epilepsy & Behavior : E&B·Sabine HellwigLudger Tebartz van Elst
Jul 13, 2016·Schizophrenia Research·Fay Y WomerDeanna M Barch
Sep 18, 2008·Neuroreport·Nuria SegarraCarme Junque
Mar 16, 2017·Brain Imaging and Behavior·Chuanjun ZhuoJiajia Zhu
Mar 10, 2020·NeuroImage·Yao WuCatherine Limperopoulos
Jul 22, 2021·Depression and Anxiety·Dong YangLiping Cao
Feb 2, 2022·Interdisciplinary Sciences, Computational Life Sciences·Yang GaoQiaolan Jia

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