Increased cerebral blood volume in HIV-positive patients detected by functional MRI

Neurology
I TraceyR G González

Abstract

To study changes in cerebral hemodynamics related to HIV infection. Cerebral injury is a well-known manifestation of HIV infection. Physiologic changes in the HIV brain may precede structural changes and may be detected by functional MRI (fMRI). Dynamic contrast fMRI was used to measure the cerebral blood volume (CBV) in 13 patients infected with HIV and in 7 healthy control subjects. Significant increases in dynamic CBV were found in the deep (p < 0.001) and cortical gray matter (p < 0.05) of HIV-positive (HIV+) patients. Patients with definite cognitive impairment showed significantly greater increases in CBV in the deep gray matter (DGM) compared with those without impairment. In one patient with rapidly progressive cognitive impairment, these abnormalities reversed and paralleled clinical improvement after initiation of zidovudine monotherapy. This study supports the hypothesis that HIV infection is associated with significant cerebral hemodynamic changes, particularly in the DGM, that may contribute to cognitive dysfunction in AIDS. Functional MRI may be useful for early detection of cerebral injury and for the assessment of novel therapies.

Citations

Jun 17, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·O SpeckT Ernst
Nov 28, 2007·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·R Gilberto GonzálezSusan Westmoreland
Aug 17, 2002·Trends in Neurosciences·Malcolm J AvisonJoseph R Berger
Mar 27, 2001·Progress in Neuro-psychopharmacology & Biological Psychiatry·D M Rausch, E S Stover
Aug 6, 2000·European Journal of Radiology·T P RobertsH C Roberts
Jan 31, 2004·Journal of the International Neuropsychological Society : JINS·Julie D RippethUNKNOWN HNRC Group
Sep 10, 2008·Journal of Neurovirology·Leslie CrewsEliezer Masliah
Jul 21, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·F CalamanteR Turner
Dec 17, 2010·AIDS·Judith SchoutenPeter Portegies
Aug 20, 2005·The Journal of Clinical Investigation·Kenneth WilliamsR Gilberto González
Sep 25, 2014·Current Opinion in HIV and AIDS·Beau M Ances, Dima A Hammoud
Jan 15, 2008·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Glenn T StebbinsMichael E Moseley
Aug 18, 2001·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·UNKNOWN European Federation of Neurological Societies Task Force
Oct 21, 2015·Neurobiology of Disease·April D ThamesSusan Y Bookheimer
Jun 1, 2006·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kyle T S PattinsonRichard G Wise
Dec 8, 2004·Journal of Neuroimmunology·Karen A TuckerColin D Hall
Dec 8, 2004·Journal of Neuroimmunology·Malcolm J AvisonJoseph R Berger
Nov 6, 2004·NeuroImage·Constantin T YiannoutsosBradford A Navia
Dec 28, 2017·Journal of Neurovirology·Ronald A CohenM-Z Ding
May 8, 2000·Science·E O MajorD Clifford

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