Increased cerebral choline-compounds in Duchenne muscular dystrophy

Neuroreport
T KatoS Takashima

Abstract

We investigated the hypothesis that cell membrane function is abnormal in brains of subjects with Duchenne muscular dystrophy (DMD) using proton-nuclear magnetic resonance (NMR) spectroscopy of human brain extracts. The total amount of choline-containing compounds was significantly higher (about three times) than in normal controls and patients with other myopathies, while N-acetyl-L-aspartic acid and creatine were within the normal range. These findings indicate that abnormal cell membrane function may be correlated with the abnormal dystrophin or lack of dystrophin in the brain of patients with DMD.

References

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Citations

Dec 19, 2000·Pediatric Neurology·T KatoY Suzuki
Dec 12, 2001·Neuromuscular Disorders : NMD·Caroline RaeStewart Head
Aug 13, 2004·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Julian L Griffin
Dec 3, 2014·Brain Research Bulletin·Erez James CohenDiego Minciacchi
Feb 9, 2002·Brain : a Journal of Neurology·J L AndersonJ W Morley
Dec 15, 2019·Molecular Neurobiology·Michael Naidoo, Karen Anthony

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