Increased cerebral responses to salient transitions between alternating stimuli in chronic migraine with medication overuse headache and during migraine attacks

Cephalalgia : an International Journal of Headache
Volodymyr B BogdanovJean Schoenen

Abstract

In a previous study exploring central pain modulation with heterotopic stimuli in healthy volunteers, we found that transitions between sustained noxious and innocuous thermal stimulations on the foot activated the "salience matrix". Knowing that central sensory processing is abnormal in migraine, we searched in the present study for possible abnormalities of these salient transitional responses in different forms of migraine and at different time points of the migraine cycle. Participants of both sexes, mostly females, took part in a conditioned pain modulation experiment: Migraineurs between (n = 14) and during attacks (n = 5), chronic migraine patients with medication overuse headache (n = 7) and healthy volunteers (n = 24). To evoke the salience response, continuous noxious cold or innocuous warm stimulations were alternatively applied on the right foot. Cerebral blood oxygenation level dependent responses were recorded with fMRI. Switching between the two stimulations caused a significant transition response in the "salience matrix" in all subject groups (effect of the condition). Moreover, some group effects appeared on subsequent post-hoc analyses. Augmented transitional blood oxygenation level dependent responses in the...Continue Reading

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Citations

Oct 11, 2019·Journal of Neural Transmission·Gianluca CoppolaFrancesco Pierelli
Feb 13, 2020·Frontiers in Neurology·Catherine D Chong

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Methods Mentioned

BETA
SMA

Software Mentioned

Cogent Graphics
Statistical Parametric Mapping
Fieldmap Toolbox
SPM
MATLAB
SPM8
Cogent
Realign and Unwarp

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