Increased cerebrospinal fluid F2-isoprostanes are associated with aging and latent Alzheimer's disease as identified by biomarkers.

Neuromolecular Medicine
Thomas J MontineDouglas Galasko

Abstract

Alzheimer's disease (AD) is a common age-related chronic illness with latent, prodrome, and fully symptomatic dementia stages. Increased free radical injury to regions of brain is one feature of prodrome and dementia stages of AD; however, it also is associated with advancing age. This raises the possibility that age-related free radical injury to brain might be caused in part or in full by latent AD. We quantified free radical injury in the central nervous system with cerebrospinal fluid (CSF) F(2)-isoprostanes (IsoPs) in 421 clinically normal individuals and observed a significant increase over the adult human lifespan (P < 0.001). Using CSF amyloid (A) β(42) and tau, we defined normality using results from 28 clinically normal individuals <50 years old, and then stratified 74 clinically normal subjects ≥60 years into those with CSF that had normal CSF Aβ(42) and tau (n = 37); abnormal CSF Aβ(42) and tau, the biomarker signature of AD (n = 24); decreased Aβ(42) only (n = 4); or increased tau only (n = 9). Increased CSF F(2)-IsoPs were present in clinically normal subjects with the biomarker signature of AD (P < 0.05) and those subjects with increased CSF tau (P < 0.001). Finally, we analyzed the relationship between age and C...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·C D SmithW R Markesbery
Jan 1, 1996·Neurobiology of Aging·S CraftA Alderson
Sep 28, 1998·Annals of Neurology·T J MontineL J Roberts
Oct 26, 1999·Neurology·T J MontineJ D Morrow
Mar 17, 2000·Free Radical Biology & Medicine·L J Roberts, J D Morrow
Jun 12, 2002·Archives of Neurology·Domenico PraticòJohn Q Trojanowski
Sep 5, 2002·Annals of Neurology·Thomas J MontineJason D Morrow
Mar 9, 2004·Journal of Alzheimer's Disease : JAD·Joseph F QuinnThomas J Montine
Mar 24, 2004·Chemistry and Physics of Lipids·Kathleen S MontineThomas J Montine
Nov 25, 2004·Annals of Neurology·Helen PetrovitchLon R White
Jan 15, 2005·Antioxidants & Redox Signaling·Thomas J MontineJason D Morrow
Aug 27, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Randy L BucknerMark A Mintun
Nov 2, 2005·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Dejan MilatovicThomas J Montine
Dec 6, 2005·Alzheimer Disease and Associated Disorders·Elaine R PeskindDouglas Galasko
May 19, 2007·Journal of Neuroscience Research·Mark A Lovell, William R Markesbery
Sep 20, 2007·Annals of Neurology·Joshua A SonnenThomas J Montine
Sep 29, 2007·Journal of Molecular Neuroscience : MN·Thomas J MontineJason D Morrow
Oct 2, 2007·Age and Ageing·Suzanne L TyasWilliam R Markesbery
Oct 16, 2007·Neuro-degenerative Diseases·M C IrizarryD Praticò
Jan 22, 2008·CNS Spectrums·Ronald C Petersen, Selamawit Negash
Jan 22, 2008·CNS Spectrums·Aaron P Nelson, Margaret G O'Connor
May 17, 2008·Free Radical Biology & Medicine·Joshua A SonnenThomas J Montine
Jul 19, 2008·Lancet Neurology·Joshua A SonnenThomas J Montine
Nov 13, 2008·Archives of Neurology·Howard Jay AizensteinWilliam E Klunk
Apr 21, 2009·Neurobiology of Aging·Joseph L PriceJohn C Morris
Jun 19, 2009·Journal of Neuropathology and Experimental Neurology·William R MarkesberyFrederick A Schmitt
Mar 10, 2010·Archives of Neurology·Hassan M Fathallah-Shaykh
Apr 8, 2010·Annals of Neurology·Dorene M RentzKeith A Johnson
Sep 8, 2010·Movement Disorders : Official Journal of the Movement Disorder Society·Thomas J MontineJing Zhang

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Citations

Jun 15, 2011·Archives of Neurology·Jennifer L Bayer-CarterSuzanne Craft
Jul 5, 2011·Current Neurology and Neuroscience Reports·Luis F Gonzalez-CuyarThomas J Montine
Jun 1, 2012·Canadian Journal on Aging = La Revue Canadienne Du Vieillissement·Nicholas Packer, Laurie Hoffman-Goetz
Nov 4, 2010·Antioxidants & Redox Signaling·Tsogzolmaa DorjgochooQi Dai
Apr 16, 2014·Neuroscience Bulletin·Xiaojing SuiXifei Yang
May 2, 2013·Neurobiology of Disease·Jonathan J SabbaghJeffrey L Cummings
Aug 26, 2014·Oxidative Medicine and Cellular Longevity·Kamila SyslováPetr Kačer
Feb 23, 2013·Mechanisms of Ageing and Development·Kimberly D JacobMichele K Evans
Mar 10, 2016·Journal of Toxicology and Environmental Health. Part a·Lee C MangumJ Allen Crow
Aug 11, 2016·Artificial Intelligence in Medicine·Ane AlberdiAdrian Basarab
Jul 20, 2014·Drug and Alcohol Dependence·Timothy C DurazzoUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 11, 2018·Oxidative Medicine and Cellular Longevity·Joanna WojsiatUrszula Wojda
Oct 4, 2019·Scientific Reports·Carmen Peña-BautistaConsuelo Cháfer-Pericás
Jan 1, 2013·Journal of Neurodegenerative Diseases·Peizhong Mao
Sep 3, 2019·Journal of Alzheimer's Disease : JAD·Rachel M ShafferGe Li
Jul 5, 2012·The American Journal of Clinical Nutrition·Tsogzolmaa DorjgochooQi Dai
Jul 19, 2019·Clinical Biochemistry·Carmen Peña-BautistaConsuelo Cháfer-Pericás
Sep 1, 2013·Comprehensive Reviews in Food Science and Food Safety·Alaa El-Din A BekhitEric N Ponnampalam
Apr 4, 2021·Cancers·Lieze BerbenSigrid Hatse

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