Increased chemokine receptor expression and the infiltration of lymphoid organs

Leukemia & Lymphoma
H Hasegawa

Abstract

Lymphocyte passage across endothelium into lymph nodes and Peyer's patches is a multistep process that involves selectin-supported rolling, followed by a triggering event, and then firm integrin-mediated adhesion. The combined actions of adhesion molecules and chemokines largely determine the migratory behavior of lymphocytes. Chemokines are known to mediate their effects through 7 transmembrane-domain G-protein-coupled receptors. Here, we review the role of chemokines and their receptors in lymphocyte's migration into lymphoid organs.

Citations

Nov 19, 2010·Cerebral Cortex·Fu-Wen Zhou, Steven N Roper
Jan 18, 2006·Journal of Pediatric Surgery·Sonya R WalkerEdward M Barksdale

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