Increased choriocapillaris vessel density in amblyopic children: a case-control study

Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus
Enrico BorrelliIrena Tsui

Abstract

To investigate the choriocapillaris in children with amblyopia, using optical coherence tomography angiography (OCT-A). Patients with amblyopia and age-matched controls were prospectively imaged using OCT-A. On OCT-A, the choriocapillaris measures 30 μm starting 31 μm posterior to the retinal pigment epithelium. The section of choriocapillaris under superficial retinal vessels was excluded from analysis to avoid shadowing or projection artifacts. The main outcome measure was choriocapillaris vessel density. Secondary outcome measures were foveal macular thickness and parafoveal macular thickness. A total of 20 eyes of 16 patients with amblyopia and 25 eyes of 25 controls were included. Mean age of amblyopic subjects was 7.6 ± 3.6 years; of controls, 9.3 ± 2.2 years (P = 0.10). Mean refractive error of subjects was 4.3 ± 6.2 D; of controls, 0.0 ± 1.6 D (P = 0.004). Mean choriocapillaris vessel density was 74.8 ± 5.8 in the amblyopic group and 71.1 ± 3.6 in the control group, which was significant even after adjusting for age and refractive error (P = 0.012). There was no difference between groups in foveal macular thickness or parafoveal macular thickness; however, outer parafoveal macular thickness (the inner boundary of the in...Continue Reading

Citations

Feb 23, 2020·Therapeutic Advances in Ophthalmology·Bradley S Gundlach, Irena Tsui
Dec 11, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Viktoria C BrücherMaged Alnawaiseh
Feb 6, 2020·Therapeutic Advances in Ophthalmology·Funda Dikkaya, Sevil Karaman Erdur
Jun 4, 2019·Seminars in Ophthalmology·Eric D GaierGena Heidary
Feb 9, 2019·Journal of Ophthalmology·Noriko TeradaAkitaka Tsujikawa
Mar 31, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christiane Al-HaddadElza Rachid
Dec 4, 2021·European Journal of Ophthalmology·Müjdat KarabulutAylin Karalezli

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