Increased Choroidal Blood Perfusion Can Inhibit Form Deprivation Myopia in Guinea Pigs.

Investigative Ophthalmology & Visual Science
Xuan ZhouXiangtian Zhou

Abstract

In guinea pigs, choroidal thickness (ChT) and choroidal blood perfusion (ChBP) simultaneously decrease in experimental myopia, and both increase during recovery. However, the causal relationship between ChBP and myopia requires further investigation. In this study, we examined the changes of ChBP with three different antimyopia treatments. We also actively increased ChBP to examine the direct effect on myopia development in guinea pigs. Experiment 1: Guinea pigs wore occluders on the right eye for two weeks to induce form-deprivation myopia (FDM). Simultaneously they received daily antimyopia treatments: peribulbar injections of atropine or apomorphine or exposure to intense light. Experiment 2: The vasodilator prazosin was injected daily into the form-deprivation eyes to increase ChBP during the two-week induction of FDM. Other FDM animals received appropriate control treatments. Changes in refraction, axial length, ChBP, ChT, and hypoxia-labeled pimonidazole adducts in the sclera were measured. The antimyopia treatments atropine, apomorphine, and intense light all significantly inhibited myopia development and the decrease in ChBP. The treatments also reduced scleral hypoxia, as indicated by the decrease in hypoxic signals. F...Continue Reading

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Citations

Jan 5, 2021·Investigative Ophthalmology & Visual Science·Hao WuXiangtian Zhou
Jun 26, 2021·Microvascular Research·Ting YuHongsheng Bi
Jul 29, 2021·Investigative Ophthalmology & Visual Science·Hao WuXiangtian Zhou
Nov 18, 2021·Investigative Ophthalmology & Visual Science·Peiyuan WangUNKNOWN GSHM study group

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