Increased circulating levels of thrombin-activatable fibrinolysis inhibitor in lung cancer patients

American Journal of Hematology
Osamu HatajiYukihiko Adachi

Abstract

Impairment of fibrinolytic function plays an important role in the mechanism of thrombotic disorders in cancer patients. This study assessed the circulating level of thrombin-activatable fibrinolysis inhibitor in patients with lung cancer and its expression by several lung cancer cell lines. The plasma concentrations of thrombin-activatable fibrinolysis inhibitor were significantly increased in lung cancer patients compared to healthy subjects. The concentration of thrombin-activatable fibrinolysis inhibitor was particularly higher in patients with small cell carcinoma compared to those with adenocarcinoma or squamous cell carcinoma, and in cancer patients that responded to chemotherapy compared to non-responders. In vitro studies showed more expression of thrombin-activatable fibrinolysis inhibitor in small cell carcinoma than in adenocarcinoma cell lines and more expression in lung cancer cell lines sensitive to anti-cancer agents than in resistant cell lines. This study suggests that thrombin-activatable fibrinolysis inhibitor, in part secreted from lung cancer cells, may play a role in the pathogenesis of thrombotic disorders in lung cancer patients.

References

Dec 1, 1991·Thrombosis Research·T HarbourneA N Nicolaides
Nov 1, 1991·American Journal of Clinical Pathology·J R Newland, W D Haire
May 1, 1989·Journal of the American College of Cardiology·H J Swan
Jun 16, 1995·The Journal of Biological Chemistry·L BajzarM E Nesheim
Mar 9, 1995·The New England Journal of Medicine·A Hamsten
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E C GabazzaT Shima
May 14, 1998·Seminars in Thrombosis and Hemostasis·J L FrancisA Amirkhosravi
Jun 5, 1999·Seminars in Thrombosis and Hemostasis·A Falanga, F R Rickles
Dec 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·L Bajzar
Feb 24, 2001·The New England Journal of Medicine·L R Zacharski, D L Ornstein
Mar 7, 2001·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·S J PaveyN A Marsh
Aug 23, 2001·Thrombosis Research·F R Rickles, A Falanga
Sep 11, 2001·Acta Haematologica·A J Gale, S G Gordon
Feb 12, 2002·The Journal of Clinical Endocrinology and Metabolism·Yasuko HoriYasuhiro Sumida
May 10, 2002·The Journal of Biological Chemistry·Michael B BoffaMarlys L Koschinsky
Mar 5, 2003·American Journal of Respiratory and Critical Care Medicine·Hajime FujimotoOsamu Taguchi

❮ Previous
Next ❯

Citations

Apr 27, 2012·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Evren FidanFazil Aydin
May 22, 2010·Veterinary Clinical Pathology·Lisbeth R JessenAnnemarie T Kristensen
May 18, 2011·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·O KaftanS K Yalcin
Mar 29, 2014·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G NielsenEvangelina B Steinbrenner
Feb 8, 2011·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Ozlem S BalcikGulsum Ozet
Dec 21, 2006·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen, Truitt C Ellis
May 13, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Vance G Nielsen
Apr 30, 2013·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Xu ChengweiWang Yunshan
May 4, 2011·Proteomics. Clinical Applications·Holger HusiJames A Ross
Dec 9, 2016·Biological Chemistry·Donna M SmallClifford C Taggart
Aug 3, 2017·Molecular Medicine Reports·Chao YuChengwei Xu
May 27, 2008·Clinical Lung Cancer·Macit KoldasNazim Serdar Turhal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre
O KaftanS K Yalcin
Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis
Ozlem S BalcikGulsum Ozet
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Evren FidanFazil Aydin
American Journal of Respiratory and Critical Care Medicine
Hajime FujimotoOsamu Taguchi
© 2022 Meta ULC. All rights reserved