Increased Circulating Proinflammatory T Lymphocytes in Children with Different Forms of Anterior Uveitis: Results from a Pilot Study

Ocular Immunology and Inflammation
Karoline WalscheidDirk Foell

Abstract

To characterize peripheral blood T cells in juvenile idiopathic arthritis-associated uveitis (JIAU). Blood samples were taken from children with JIAU (n = 18), JIA without ocular involvement (n = 11), idiopathic anterior uveitis (IAU, n = 12), and healthy controls (n = 11). Cells were stained for T cell surface markers, and intracellular cytokine staining was performed after cell stimulation and analyzed by flow cytometry. The Th1/Th2 ratio was increased in JIAU patients. Numbers of IL-13-expressing cells an level of IL-13 and IL-10 expression per cell were increased in all patient groups; whereas, percentages of IL-5-expressing T cells were decreased. Numbers of proinflammatory Th17 cells and T cells expressing CTLA-4 were increased in all patient groups; whereas, γ/δ T cell numbers were decreased. Results from JIA and IAU were similar. T cell subtypes and potential T cell function are altered in pediatric patients with uveitis and arthritis as compared to healthy children.

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Citations

Mar 16, 2019·Expert Review of Clinical Immunology·Anne-Mieke J W HaasnootJoke H de Boer
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Jul 14, 2021·Investigative Ophthalmology & Visual Science·Roos A W WenninkJonas J W Kuiper
Aug 28, 2021·Children·Emil CarlssonChristian M Hedrich

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