PMID: 7212504Apr 1, 1981Paper

Increased clearance of propranolol in thyrotoxicosis

Annals of Internal Medicine
J FeelyJ Crooks

Abstract

The pharmacokinetics of oral propranolol were studied during chronic treatment in six patients when thyrotoxic and again when euthyroid. The mean total plasma propranolol steady-state concentration was 42% lower when the patients were thyrotoxic. After treatment of thyrotoxicosis there was a fall (P less than 0.05) in the oral clearance of both total (4.2 +/- 0.6 to 2.7 +/- 0.4 L/min, mean +/- SEM) and free (30.5 +/- 4.7 to 25.5 +/- 4.1 L/min) propranolol although the half-life of propranolol did not change significantly. The free fraction of propranolol was higher (p less than 0.05) in the thyrotoxic (14.2% +/- 1.3%) than in the euthyroid (11.4% +/- 0.8%) state. These results suggest that the pharmacokinetics of propranolol are significantly altered in thyrotoxicosis.

Citations

Jan 1, 1987·European Journal of Clinical Pharmacology·M PokrajacV M Varagić
Jan 1, 1988·Pharmacology & Therapeutics·J W UpwardC F George
Nov 18, 1982·The New England Journal of Medicine
Apr 1, 1984·Anaesthesia·W F HamiltonJ Feely
Jun 1, 1982·British Journal of Clinical Pharmacology·N R PedenJ Crooks
Jun 13, 2003·Endocrinology and Metabolism Clinics of North America·Roy W Langley, Henry B Burch
Sep 1, 1993·Postgraduate Medicine·William L Isley
Jan 1, 1985·European Journal of Clinical Pharmacology·R L Smith

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