PMID: 8972254Oct 1, 1996Paper

Increased concentrations of octachlorodibenzo-p-dioxin in cases with breast cancer--results from a case-control study

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
L HardellA Magnuson

Abstract

Organochlorines are persistent and highly lipophilic environmental contaminants which bioaccumulate in the food chain. Some of these chemicals, 2,2-bis(p-chlorophenyl)-1,1,1-trichloroethane (DDT) and polychlorinated biphenyls (PCBs), have been suggested to be of significance in the aetiology of breast cancer. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is an anti-oestrogen in animal studies and should be thus lower the risk of breast cancer. The other isomers of polychlorinated dibenzo-p-dioxins (PCDDs) or the chemically related polychlorinated dibenzofurans (PCDFs) have not been tested regarding carcinogenesis of the breast. The purpose of this study was to investigate whether PCDDs or PCDFs influence the risk for breast cancer. Consecutive patients who underwent surgery for a breast disease between 1993 and 1995 were recruited for the study. Cases were 22 patients with infiltrative breast cancer and controls were 19 patients operated for a benign breast disease during the same time period. Approximately 10 g of breast tissue free from tumour was taken from the specimen and frozen until analysis. Fat was extracted, cleaned and analysed with a high-resolution gas chromatograph coupled to a high-resolution mass spectrometer. Medi...Continue Reading

Citations

Jun 30, 2005·Cancer Causes & Control : CCC·Peggy ReynoldsStefanie S Jeffrey
Dec 6, 2001·Journal of Hazardous Materials·Mohamed Tawfic AhmedEinas El Shiekh
Jun 5, 1998·Annual Review of Public Health·F Laden, D J Hunter
Jul 16, 2002·Environmental Health Perspectives·Marcella WarnerPaolo Brambilla
Mar 9, 2006·Best Practice & Research. Clinical Endocrinology & Metabolism·P D Darbre
Jul 2, 2011·Critical Reviews in Toxicology·Paolo BoffettaJack S Mandel
Sep 16, 2016·Environmental Science and Pollution Research International·Tafzila Akter Mouly, Leisa-Maree Leontjew Toms
May 16, 2007·Cancer·Julia Green BrodyRuthann A Rudel

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