Increased consumption but not operant self-administration of ethanol in mice lacking the RIIbeta subunit of protein kinase A.

Alcoholism, Clinical and Experimental Research
Frank M FerraroTodd E Thiele

Abstract

Accumulating evidence indicates that adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) is involved in the neurobiological responses to ethanol. Previous reports indicate that mice lacking the RIIbeta subunit of PKA (RIIbeta(-/-)) voluntarily consume more ethanol than wild-type controls (RIIbeta(+/+)) using 2-bottle testing procedures. Although such procedures primarily measure consummatory behavior, operant self-administration procedures allow analysis of consummatory as well as appetitive or "ethanol-seeking" behavior (i.e., lever pressing is required to gain access to the ethanol solution). Therefore, we determined whether the high ethanol consumption characteristic of RIIbeta(-/-) mice would be complemented by increased appetitive ethanol-seeking behavior in an operant paradigm. RIIbeta(-/-) (n=8) and RIIbeta(+/+) (n=8) mice were initially sucrose-faded until they were lever responding for nonsweetened ethanol (10, 14, and 18%). Following the self-administration testing, RIIbeta(+/+) and RIIbeta(-/-) mice were given access to 2 bottles, one containing water and the other ethanol to replicate the voluntary ethanol drinking data previously from our laboratory. Finally, immediately after voluntary consumption all ...Continue Reading

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Citations

Sep 12, 2006·Addiction Biology·John C CrabbeGeorge F Koob
Apr 10, 2008·Genes, Brain, and Behavior·D KapfhamerS L McIntire
Oct 22, 2013·Pharmacology, Biochemistry, and Behavior·Boris Tabakoff, Paula L Hoffman
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Jan 28, 2014·Alcoholism, Clinical and Experimental Research·Kelly KentRuth I Wood
Apr 13, 2011·Biological Psychiatry·Sylvane DesrivièresBoris Tabakoff
Feb 10, 2021·Brain Sciences·Bryan E JensenAngela R Ozburn

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