Increased Cortical Porosity in Older Men With Fracture

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Daniel SundhMattias Lorentzon

Abstract

Cortical porosity increases with age and affects bone strength, but its association with fracture in older men is unknown. The aim of this study was to investigate whether cortical porosity is associated with prevalent fractures in older men. A subsample of 456 men aged 80.2 ± 3.5 (mean ± SD) years, with available high-resolution peripheral quantitative computed tomography measurements at the tibia from the 5-year follow-up exam, was drawn from the prospective MrOS Gothenburg study. Dual-energy X-ray absorptiometry was used to measure areal bone mineral density (aBMD). Data on physical activity, calcium intake, medications, diseases, and smoking were collected on questionnaires at the follow-up exam. Of 87 men (19.1%) with fracture at or after age 50 years (all fracture group), 52 (11.4%) had had a self-reported fracture before the baseline exam and 35 (7.7%) had had an X-ray-verified fracture between baseline and follow-up. Men in the all-fracture group and in the X-ray-verified group had 15.8% (13.2% ± 4.9% versus 11.4% ± 3.8%; p < 0.001) and 21.6% (14.1% ± 5.2% versus 11.6% ± 3.9%; p < 0.01) higher cortical porosity, respectively, than men in the nonfracture group. The independent associations between bone microstructure par...Continue Reading

References

Mar 1, 1992·American Journal of Epidemiology·M C NevittD M Black
Jul 3, 1999·Journal of Clinical Epidemiology·R A WashburnR A Boileau
Mar 7, 2000·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T V NguyenJ A Eisman
May 29, 2000·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A A IsmailA J Silman
May 26, 2004·Archives of Internal Medicine·Ethel S SirisMarc L Berger
Jun 4, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L J MeltonB L Riggs
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
Apr 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dan MellströmClaes Ohlsson
Dec 22, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Elisabeth Sornay-RenduPierre D Delmas
Jun 4, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Dan MellströmClaes Ohlsson
Jul 18, 2008·Radiology·Aranee TechawiboonwongFelix W Wehrli
Aug 29, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L J MeltonS Khosla
Jun 22, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Emily M SteinElizabeth Shane
Mar 25, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Claes OhlssonLiesbeth Vandenput
May 26, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcRoland Chapurlat
Jul 24, 2012·The Journal of Clinical Endocrinology and Metabolism·Emily M SteinElizabeth Shane
Apr 5, 2013·The Journal of Bone and Joint Surgery. American Volume·Tamara D RozentalMary L Bouxsein
Feb 13, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yohann BalaEgo Seeman
Mar 4, 2014·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Martin NilssonMattias Lorentzon
Apr 4, 2014·The Journal of Clinical Endocrinology and Metabolism·Liesbeth VandenputClaes Ohlsson

❮ Previous
Next ❯

Citations

Nov 21, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·D SundhM Lorentzon
Oct 21, 2016·Journal of Internal Medicine·D SundhM Lorentzon
May 31, 2016·International Journal of Environmental Research and Public Health·Andrea PalermoSilvia Manfrini
Nov 8, 2016·BoneKEy Reports·Åshild Bjørnerem
Jan 18, 2017·Journal of Internal Medicine·D SundhM Lorentzon
Dec 13, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Anna G NilssonMattias Lorentzon
Jun 1, 2017·Journal of Magnetic Resonance Imaging : JMRI·Min Chen, Huishu Yuan
Nov 4, 2016·Physiological Reviews·Maria AlmeidaStavros C Manolagas
Apr 26, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Pawel SzulcRoland Chapurlat
Apr 7, 2018·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa LangsetmoUNKNOWN Osteoporotic Fractures in Men (MrOS) Study Research Group
Feb 3, 2016·Therapeutic Advances in Musculoskeletal Disease·Peggy M CawthonNancy E Lane
Jun 6, 2018·Expert Opinion on Drug Discovery·D MerlottiL Gennari
Nov 15, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M OsimaÅ Bjørnerem
Sep 20, 2017·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa JohanssonMattias Lorentzon
Apr 3, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Na Ri KimDirk Vanderschueren
Mar 11, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Natalie E CusanoJohn P Bilezikian
Nov 16, 2016·Physics in Medicine and Biology·A OstertagC Chappard
Feb 10, 2017·Current Osteoporosis Reports·Jeri W Nieves
Jun 17, 2020·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Lisa JohanssonMattias Lorentzon
Mar 30, 2021·JBMR Plus·Alessandra CarrieroSandra J Shefelbine
May 4, 2021·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Liana Tripto-ShkolnikInbal Goldshtein
May 24, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J P van den BerghR Chapurlat
Jul 16, 2021·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·A DemingerH Forsblad-d'Elia
Sep 12, 2020·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Sanchita AgarwalMarcella Walker
Sep 30, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Wing-Hoi CheungLing Qin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Robert RudängMattias Lorentzon
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Anna DarelidMattias Lorentzon
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Pawel SzulcRoland Chapurlat
Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research
Hans JutbergerDan Mellström
The Journal of Clinical Endocrinology and Metabolism
Liesbeth VandenputClaes Ohlsson
© 2021 Meta ULC. All rights reserved