PMID: 2509834Jan 1, 1989Paper

Increased covalent binding of acetaldehyde to calmodulin in the presence of calcium

Life Sciences
R B JennettD J Tuma

Abstract

The regulatory protein, calmodulin, undergoes major conformational changes in response to changes in intracellular calcium concentration. Furthermore, calmodulin has been reported to have lysine residues which markedly increase their reactivity toward electrophilic substances in the calcium-loaded state. We found that calmodulin formed two to three times more stable adducts with acetaldehyde in the calcium-loaded state as compared to the calcium-free state. Competition-binding studies showed that calmodulin could preferentially compete with albumin for acetaldehyde in the presence, but not in the absence, of calcium. When calmodulin was in the calcium-loaded state, trifluoperazine, an inhibitor of calmodulin activity, significantly decreased the stable binding of acetaldehyde to the protein, whereas in the calcium-free state, minimal effects on binding were observed. Since calmodulin is involved in regulation of multiple important processes in the cell, it is possible that acetaldehyde-calmodulin adducts could contribute to liver injury by perturbation of calcium-dependent homeostatic mechanisms within the hepatocyte.

References

Jan 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R B JennettD J Tuma
Jan 1, 1987·Archives of Biochemistry and Biophysics·D P GiedrocK Brew
Feb 1, 1988·The Journal of Clinical Investigation·R C LinL Lumeng
Jul 1, 1987·Archives of Biochemistry and Biophysics·R B JennettD J Tuma
Jul 1, 1985·Alcoholism, Clinical and Experimental Research·M F Sorrell, D J Tuma
Jan 29, 1982·Biochemical and Biophysical Research Communications·R Gopalakrishna, W B Anderson
Jan 1, 1983·Archives of Biochemistry and Biophysics·T M DonohueM F Sorrell

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Citations

Nov 6, 2009·Genes & Nutrition·Blythe D ShepardPamela L Tuma
Feb 1, 1993·Alcoholism, Clinical and Experimental Research·T HoffmannD J Tuma
Feb 1, 1994·Alcoholism, Clinical and Experimental Research·L W KlassenG M Thiele
Feb 24, 1999·Alcoholism, Clinical and Experimental Research·H Anni, Y Israel
Jun 8, 2001·Alcoholism, Clinical and Experimental Research·G M ThieleN Nagata
Jan 1, 1991·Annals of the New York Academy of Sciences·D J TumaM F Sorrell
Mar 20, 2010·World Journal of Gastroenterology : WJG·Blythe D Shepard, Pamela L Tuma
Nov 19, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Blythe D ShepardPamela L Tuma
Sep 20, 2005·Journal of Hepatology·George T KannarkatPamela L Tuma
Jun 18, 2011·Journal of Enzyme Inhibition and Medicinal Chemistry·Fatemeh BootorabiSeppo Parkkila
Jan 1, 1991·Drug Metabolism Reviews·F J Leinweber
Mar 1, 1997·The American Journal of Forensic Medicine and Pathology·J J SteinbergA Cajigas
Sep 3, 2017·American Journal of Physiology. Gastrointestinal and Liver Physiology·Erin E DoodyPamela L Tuma
Feb 10, 2018·Trends in Molecular Medicine·Helen M HeymannEric R Gross

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