Increased cryptococcal meningitis mortality among HIV negative, non-transplant patients: a single US center cohort study

Therapeutic Advances in Infectious Disease
Gabriel MotoaAndrés F Henao-Martínez

Abstract

Cryptococcal meningitis (CM) is an opportunistic fungal infection associated with human immunodeficiency virus (HIV) and other forms of immunosuppression. We lack a clear understanding of CM associated mortality among HIV-negative, non-transplant patients in the United States (US). This article compares clinical features and outcomes across HIV status in patients with laboratory-confirmed CM. A retrospective cohort study was performed that included adult patients with laboratory-confirmed CM treated at an academic tertiary hospital between January 2000 and September 2018. Those with a history of organ transplant or non-meningeal infections were excluded. Data were gathered on demographics, HIV status, clinical presentation, cerebrospinal fluid (CSF) profiles, neurological outcomes, hospital course, and mortality. A total of 70 patients with cryptococcal disease were identified. Our final sample included 36 CM patients, mean age was 48.8 ± 13.2 years; of this group, 66.7% (n = 24) had HIV. Median [interquartile range (IQR)] absolute CD4 count for the HIV group was 35 cells/μl (10-80 cells/μl). Non-HIV/non-transplant patients were significantly older (p < 0.001) and had higher rates of altered mental status (AMS) on presentation ...Continue Reading

References

Jul 31, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P G PappasW E Dismukes
May 23, 2012·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chia-Hung LiaoJen-Hsian Wang
Mar 5, 2013·PloS One·Vasilios PyrgosPeter R Williamson
Aug 10, 2016·Mycopathologia·Andrés F Henao-MartínezJ David Beckham
May 10, 2017·The Lancet Infectious Diseases·Radha RajasinghamDavid R Boulware
Oct 14, 2017·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ige A GeorgeCarlos A Q Santos
Jan 19, 2019·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Daniel Vela-DuarteAndrés F Henao-Martínez

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