Increased CSF tau is associated with a higher risk of seizures in patients with Alzheimer's disease

Epilepsy & Behavior : E&B
Miguel Tábuas-PereiraIsabel Santana

Abstract

Neurofibrillary tangles and tau protein, the neuropathological hallmarks of Alzheimer's disease (AD), have been identified in patients with epilepsy. Tau protein was also associated with the modulation of neuronal excitability in animal models of AD. We evaluated in 292 patients with AD the association between the risk of seizure development and AD cerebrospinal fluid (CSF) biomarkers, demographic characteristics, baseline Mini-Mental State Examination (MMSE) score, comorbidities, and apolipoprotein E status. The development of seizures was associated with younger age at dementia's onset, lower baseline MMSE, and higher CSF total tau protein levels, but only MMSE (hazard ratio [HR] = 0.935; 95% confidence interval [CI] = [0.903, 0.968]; p < 0.001) and CSF tau (HR = 1.001; 95%CI = [1.001, 1.002]; p = 0.001) were independent predictors on multivariate analysis. While CSF tau and lower baseline MMSE association with seizure development could in part be explained by a greater degree of cortical damage, the role of tau in the modulation of neuronal excitability may also play a role and should be further investigated.

Citations

Nov 11, 2019·Diagnostics·Andrew J Larner
May 3, 2020·International Journal of Molecular Sciences·Ramon Cacabelos
Jun 4, 2020·Phytotherapy Research : PTR·Milad AshrafizadehKwang Seok Ahn
Apr 4, 2020·Neurocase·Saloua FraySamir Belal
Mar 20, 2021·Journal of the American Geriatrics Society·Ying XuRuth Peters

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