PMID: 3771051Oct 1, 1986Paper

Increased cutaneous fibrinolytic activity in aquagenic pruritus

International Journal of Dermatology
T LottiE Panconesi

Abstract

Aquagenic pruritus is a disease in which itchy prickling skin discomfort is evoked by contact with water at any temperature without observable cutaneous lesions. Little is known about its etiology and pathogenesis. Previous reports show that increased levels of blood histamine and cutaneous mast cell degranulation are present before water exposure and that they increase still further with water challenge. This paper shows that fibrinolytic activity is markedly increased both before and after water exposure, while circulating fibrinolytic activity is normal before water exposure in three cases of aquagenic pruritus. A patient who was asymptomatic at the time of the study had no observed increase in fibrinolytic activity either before or after water challenge, suggesting that the remission of symptoms of aquagenic pruritus and normalization of cutaneous fibrinolytic activity are interdependent factors.

References

Jan 1, 1984·International Journal of Dermatology·T LottiE Panconesi
Jun 20, 1981·British Medical Journal·M W GreavesA Coutts
Mar 1, 1983·International Journal of Dermatology·G BianchiniP Fabbri
Feb 1, 1958·American Journal of Clinical Pathology·K N VON KAULLA, R L SCHULTZ

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Citations

Jul 1, 1987·Clinics in Dermatology·E Panconesi, T Lotti
Feb 28, 2001·Journal of Pain and Symptom Management·M Krajnik, Z Zylicz
Oct 4, 2011·Indian Journal of Dermatology·C Shanmuga SekarSheja Jacob
Feb 1, 1994·Journal of the American Academy of Dermatology·T LottiD Tsampau
Jul 1, 1987·Clinics in Dermatology·H K Steinman
Jul 6, 2010·European Journal of Clinical Investigation·Kamal S SainiAyalew Tefferi
Mar 1, 1995·Pain·P Procacci, M Maresca
Apr 4, 2017·Indian Journal of Dermatology, Venereology and Leprology·Neel PrabhaRipudaman Arora
Nov 22, 2005·Dermatologic Therapy·Margherita TerranovaTorello Lotti
Mar 1, 1996·International Journal of Dermatology·P TeofoliT Lotti
Jun 21, 2012·Journal of Cutaneous Medicine and Surgery·Sari M Herman-Kideckel, Karen Binkley
Dec 23, 2019·Clinics in Dermatology·Kalina Welz-KubiakJacek C Szepietowski

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