PMID: 7539725Jun 1, 1995Paper

Increased cytolytic T lymphocyte activity and decreased B7 responsiveness are associated with CD28 down-regulation on CD8+ T cells from HIV-infected subjects

Clinical and Experimental Immunology
J H VingerhoetsJ L Ceuppens

Abstract

The CD28 receptor on CD4+ and CD8+ T cells interacts with B7 molecules on antigen-presenting cells (APC) to generate essential costimulatory signals. The cytolytic potential of CD8+ T cells could be linked to CD28 expression. Since HIV induces dysfunction of both CD4+ and CD8+ T cells, we evaluated CD28 expression and function in both subsets during HIV infection. CD28 expression on CD8+ T cells from HIV+ subjects was strongly reduced in a disease stage-related fashion. CD28- CD8+ T cells preferentially expressed CD57 and CD11b, but lacked CD26 and IL-2R alpha. The CD8+ T cells from the patients showed a significantly reduced proliferative response to co-stimulation with cell-bound anti-CD3 and B7. Nevertheless, when stimulated with plate-fixed anti-CD3, CD8+ T cells from HIV-infected subjects proliferated normally, and normal levels of IL-2R alpha and transferrin-receptor could be induced on CD28- CD8+ T cells from the patients. In addition, stimulation with plate-fixed anti-CD3 induced proliferative responses in highly purified CD28- CD8+ T cells from both HIV- and HIV+ persons. Furthermore, the increased cytotoxic activity of peripheral blood mononuclear cells (PBMC) from HIV+ subjects, measured in an anti-CD3 redirected ass...Continue Reading

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Citations

Oct 1, 1996·Immunological Reviews·S W Van GoolJ L Ceuppens
Nov 25, 2003·Pediatric Research·Mohamed Abdelhaye Elbou OuldGhislaine Sterkers
Feb 18, 2004·DNA and Cell Biology·Max W RichardsonJay Rappaport
Apr 19, 2005·Expert Opinion on Biological Therapy·L R Meireles-de-Souza, Robin J Shattock
Feb 12, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stanley T ParishRita B Effros
Nov 14, 1997·The Journal of Experimental Medicine·D HamannR A van Lier
Feb 26, 2000·Clinical and Experimental Immunology·H Choremi-PapadopoulouT Kordossis
Aug 12, 1999·Clinical and Experimental Immunology·G VanhamJ L Ceuppens
Apr 8, 1999·Clinical and Experimental Immunology·K SteinerB M Bröker
Feb 13, 2003·AIDS Research and Human Retroviruses·Christopher P LocherJay A Levy
May 11, 2005·Immunological Reviews·Rita B EffrosJanice Man
Jun 1, 2018·The Journal of Clinical Investigation·Lorraine YeoMark Peakman
Oct 27, 2001·Clinical and Experimental Immunology·K SteinerB M Bröker
May 3, 2002·Clinical and Experimental Immunology·S NabeshimaJ Hayashi
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