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Increased de novo copy number variants in the offspring of older males

Translational Psychiatry

Aug 30, 2011

T Flatscher-BaderJ Allie McGrath

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Abstract

The offspring of older fathers have an increased risk of neurodevelopmental disorders, such as schizophrenia and autism. In light of the evidence implicating copy number variants (CNVs) with schizophrenia and autism, we used a mouse model to explore the hypothesis that the offspring of ...read more

Mentioned in this Paper

Mice, Inbred C57BL
Paternal Age
Alcohol Related Neurodevelopmental Disorder
Behavior, Animal
Schizophrenia
SMAD5-AS1 gene
Linked Gene
Ilex paraguayensis homeopathic preparation
Brain Development
DNA Copy Number Changes
Paper Details
References
  • References74
  • Citations19
12

Increased de novo copy number variants in the offspring of older males

Translational Psychiatry

Aug 30, 2011

T Flatscher-BaderJ Allie McGrath

PMID: 22832608

DOI: 10.1038/tp.2011.30

Abstract

The offspring of older fathers have an increased risk of neurodevelopmental disorders, such as schizophrenia and autism. In light of the evidence implicating copy number variants (CNVs) with schizophrenia and autism, we used a mouse model to explore the hypothesis that the offspring of ...read more

Mentioned in this Paper

Mice, Inbred C57BL
Paternal Age
Alcohol Related Neurodevelopmental Disorder
Behavior, Animal
Schizophrenia

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Paper Details
References
  • References74
  • Citations19
12

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