Abstract
To investigate a potential role of lipoprotein(a) [Lp(a)] in foam cell formation, we have measured the degradation rates of Lp(a) and LDL in the rabbit aorta in vivo. Lp(a) (or LDL) was labeled with both 113I-TC and 125I and injected into 17 rabbits with extensive aortic atherosclerosis and into 16 rabbits without atherosclerosis. As the protein moiety of the doubly labeled lipoproteins is degraded, 131I-TC is trapped in the cell, whereas 125I diffuses out of the cell. Twenty-four hours after injection, 12 samples of the aorta and biopsies from 9 other tissues were removed. The degradation rate of Lp(a) (percent of plasma pool per gram tissue per day) was less than that of LDL in the adrenals and in the intestine. In contrast, degradation rates of Lp(a) and LDL were similar in liver, spleen, kidney, heart, lung, skeletal muscle, and adipose tissue. In nonlesioned aortic intima-inner media, the degradation rate of Lp(a) was 39% of that of LDL (t test: P <.05 in aortic arch and thoracic aorta), whereas the degradation rates of Lp(a) and LDL were similar in atherosclerotic aortic intima-inner media. Lp(a) degradation rates were markedly increased in atherosclerotic compared with nonlesioned aortic intima-inner media: 28.2+/-9.2 x ...Continue Reading
References
Mar 1, 1991·The Journal of Clinical Investigation·T F ZioncheckR M Lawn
Apr 1, 1991·Atherosclerosis·B L KnightM Seed
Mar 1, 1990·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J LoscalzoA M Scanu
Jan 1, 1990·Virchows Archiv. A, Pathological Anatomy and Histopathology·A NiendorfM Dietel
May 25, 1989·Nature·K A HajjarR L Nachman
Nov 17, 1989·Science·G Utermann
May 25, 1989·Nature·L A MilesE F Plow
Nov 1, 1989·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·D C Schwenke, T E Carew
Aug 1, 1987·The Journal of Clinical Investigation·G UtermannC Seitz
Nov 1, 1988·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·M Bihari-VargaG M Kostner
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D L EatonA M Scanu
Jan 1, 1986·Methods in Enzymology·M J Chapman
Jan 1, 1986·Methods in Enzymology·L L RudelF L Johnson
Feb 21, 1972·Biochimica Et Biophysica Acta·D W BilheimerR I Levy
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P T KovanenJ L Goldstein
May 1, 1984·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·T E CarewD Steinberg
Jun 15, 1983·The Biochemical Journal·R C PittmanA D Attie
Oct 1, 1994·Journal of Cardiovascular Pharmacology·L S JacobssonA G Olsson
Jun 15, 1994·Annals of Internal Medicine·D J RaderH B Brewer
Mar 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·B F HansenB G Nordestgaard
Jul 5, 1993·FEBS Letters·W MärzW Gross
Jun 11, 1993·Science·D J GraingerR M Lawn
Feb 1, 1996·The Journal of Clinical Investigation·V MooserH H Hobbs
Jul 15, 1996·The Journal of Clinical Investigation·L B NielsenB G Nordestgaard
Jul 5, 1958·Nature·A S McFARLANE
Citations
Jul 23, 2009·JAMA : the Journal of the American Medical Association·UNKNOWN Emerging Risk Factors CollaborationJohn Danesh
Jul 21, 2011·Current Atherosclerosis Reports·Sandeep S Mangalmurti, Michael H Davidson
Apr 27, 1999·Atherosclerosis·L B Nielsen
Apr 7, 1999·Current Opinion in Cardiology·L J SemanE J Schaefer
Nov 13, 1998·Current Opinion in Lipidology·K J Williams, I Tabas
Jun 30, 2010·Journal of Lipid Research·Tanja X PedersenLars B Nielsen
May 19, 2010·Biomarkers in Medicine·Pia R Kamstrup, Børge G Nordestgaard
Nov 9, 2012·Clinical Lipidology·Qibin Qi, Lu Qi
Apr 2, 2014·Lipids in Health and Disease·Tsuyoshi NozueIchiro Michishita
Sep 3, 2014·Nature Reviews. Endocrinology·Majken K JensenKenneth J Mukamal
Feb 14, 2017·International Journal of Biological Macromolecules·Kai QuZuo Wang
Nov 3, 2016·Journal of Lipid Research·Børge G Nordestgaard, Anne Langsted
Oct 19, 2010·Journal of Psychopharmacology·Georgios PaslakisMichael Deuschle
Oct 28, 2010·Current Opinion in HIV and AIDS·Signe W Worm, Priscilla Hsue
Apr 5, 2014·Molecular and Cellular Biochemistry·Xiaolong LinZuo Wang
Feb 11, 2020·Coronary Artery Disease·Gema MiñanaJulio Núñez
Jan 15, 2011·Scandinavian Journal of Clinical and Laboratory Investigation·Pia R KamstrupBørge G Nordestgaard
Aug 7, 2008·The Journal of Clinical Endocrinology and Metabolism·Pia R KamstrupBørge G Nordestgaard
Mar 5, 2016·Heart and Vessels·Takayuki MitsudaToyoaki Murohara
May 10, 2020·Heart·Hui-Hui LiuJian-Jun Li
Apr 30, 2003·The American Journal of Clinical Nutrition·Lissa M GattoSamir Samman
Apr 13, 2000·International Journal of Experimental Pathology·G A Ferns, T Y Avades
Sep 16, 2015·Current Diabetes Reports·Leah E CahillMajken K Jensen
Jan 29, 2010·Atherosclerosis·Pia R Kamstrup
Jun 22, 2021·Journal of Cardiovascular Translational Research·Yongkui RenDa Yin
Jun 29, 2011·Atherosclerosis·Pamela SongGyeong-Moon Kim