Increased density of DISC1-immunoreactive oligodendroglial cells in fronto-parietal white matter of patients with paranoid schizophrenia

European Archives of Psychiatry and Clinical Neuroscience
Hans-Gert BernsteinBernhard Bogerts

Abstract

Profound white matter abnormalities have repeatedly been described in schizophrenia, which involve the altered expression of numerous oligodendrocyte-associated genes. Transcripts of the disrupted-in-schizophrenia 1 (DISC1) gene, a key susceptibility factor in schizophrenia, have recently been shown to be expressed by oligodendroglial cells and to negatively regulate oligodendrocyte differentiation and maturation. To learn more about the putative role(s) of oligodendroglia-associated DISC1 in schizophrenia, we analyzed the density of DISC1-immunoreactive oligodendrocytes in the fronto-parietal white matter in postmortem brains of patients with schizophrenia. Compared with controls (N = 12) and cases with undifferentiated/residual schizophrenia (N = 6), there was a significantly increased density of DISC1-expressing glial cells in paranoid schizophrenia (N = 12), which unlikely resulted from neuroleptic treatment. Pathophysiologically, over-expression of DISC1 protein(s) in white matter oligodendrocytes might add to the reduced levels of two myelin markers, 2',3'-cyclic-nucleotide 3'-phosphodiesterase and myelin basic protein in schizophrenia. Moreover, it might significantly contribute to cell cycle abnormalities as well as to ...Continue Reading

References

Feb 17, 1999·The Journal of Neuropsychiatry and Clinical Neurosciences·B BaumannB Bogerts
Apr 11, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y HakakA A Fienberg
Dec 5, 2002·Neurochemical Research·Patrick R HofJoseph D Buxbaum
May 2, 2003·The British Journal of Psychiatry : the Journal of Mental Science·J BurnsS M Lawrie
Sep 25, 2003·The Journal of Nervous and Mental Disease·Brian KirkpatrickRosalinda C Roberts
Sep 27, 2003·Schizophrenia Research·Gianfranco SpallettaCarlo Caltagirone
Jul 2, 2005·NeuroImage·Serge A MitelmanLina Shihabuddin
May 9, 2006·Trends in Molecular Medicine·David J Porteous, J Kirsty Millar
Jun 1, 2006·The Journal of Comparative Neurology·Brian KirkpatrickRosalinda C Roberts
Dec 15, 2007·Biological Psychology·Philip R SzeszkoAnil K Malhotra
Mar 7, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pavel KatselVahram Haroutunian
Sep 9, 2008·Acta Neuropathologica·Andrea SchmittPeter Falkai
Jun 26, 2009·Current Opinion in Psychiatry·Marinos Kyriakopoulos, Sophia Frangou
Jul 11, 2009·Expert Review of Neurotherapeutics·Hans-Gert BernsteinBernhard Bogerts
Aug 25, 2009·Journal of Psychiatric Research·Daniel Martins-de-Souza
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kenji NakataJoel E Kleinman
Mar 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Saurav SeshadriAkira Sawa
Mar 12, 2010·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Nadine FarkasHans-Gert Bernstein
Oct 5, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ivica KostovićGoran Sedmak
Mar 2, 2011·Molecular Psychiatry·E SprootenA M McIntosh
Jun 7, 2011·NeuroImage·Stefan BraunsStefan Ehrlich
Jul 5, 2011·Expert Review of Neurotherapeutics·Mark WalterfangChristos Pantelis
Aug 26, 2011·European Archives of Psychiatry and Clinical Neuroscience·Andrea SchmittPeter Falkai
Nov 26, 2011·ACS Chemical Neuroscience·Dinesh C SoaresDavid J Porteous
Nov 14, 2012·Neurobiology of Disease·Nagahide Takahashi, Takeshi Sakurai
Nov 21, 2012·The International Journal of Neuropsychopharmacology·Yuan RenLan Xiao
Jan 4, 2013·Cerebral Cortex·Rebecca C KnickmeyerJohn H Gilmore
Apr 23, 2013·Schizophrenia Research·Barbara J DuffDouglas H R Blackwood
Aug 21, 2013·Schizophrenia Bulletin·Andrea GoudriaanMark H G Verheijen
May 21, 2014·Psychiatry Investigation·Javier Vázquez-BourgonBenedicto Crespo-Facorro

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Citations

Jan 13, 2018·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hans-Gert BernsteinJohann Steiner
Sep 9, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·N S Kolomeets
May 20, 2020·Frontiers in Psychiatry·Danielle Gouvêa-JunqueiraFernanda Crunfli
Jan 13, 2021·Schizophrenia Research·Kirsten E Schoonover, Rosalinda C Roberts

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