Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer.

Endocrine-related Cancer
Mabel RyderJames A Fagin

Abstract

Thyroid cancers are infiltrated with tumor-associated macrophages (TAMs), yet their role in cancer progression is not known. The objectives of this study were to characterize the density of TAMs in well-differentiated (WDTC), poorly differentiated (PDTC), and anaplastic thyroid cancers (ATC) and to correlate TAM density with clinicopathologic parameters. Immunohistochemistry was performed on tissue microarray sections from WDTC (n=33), PDTC (n=37), and ATC (n=20) using macrophage-specific markers. Electronic medical records were used to gather clinical and pathologic data. Follow-up information of PDTC patients was available for 0-12 years. In total, 9 out of 33 WDTC (27%), 20 out of 37 PDTC (54%), and 19 out of 20 ATC (95%) had an increased density of CD68(+) TAMs (> or = 10 per 0.28 mm(2); WDTC versus PDTC, P=0.03; WDTC versus ATC, P<0.0001; PDTC versus ATC, P<0.002). Increased TAMs in PDTC was associated with capsular invasion (P=0.034), extrathyroidal extension (P=0.009), and decreased cancer-related survival (P=0.009) compared with PDTC with a low density of TAMs. In conclusion, the density of TAMs is increased in advanced thyroid cancers. The presence of a high density of TAMs in PDTC correlates with invasion and decrease...Continue Reading

References

Nov 1, 1995·American Journal of Surgery·P E AndersenJ P Shah
Jan 1, 1994·Journal of Cancer Research and Clinical Oncology·G HerrmannK Hübner
May 1, 1997·The Journal of Clinical Endocrinology and Metabolism·A FiumaraP Gangemi
Jan 5, 1999·American Journal of Surgery·D K DharN Nagasue
Sep 6, 2002·The American Journal of Pathology·Sebastian F SchoppmannDontscho Kerjaschki
Oct 26, 2002·Cancer Cell·Léon C L van Kempen, Lisa M Coussens
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Jung Hwan HwangMinho Shong
Jan 21, 2006·Cancer Research·Claire E Lewis, Jeffrey W Pollard
Nov 23, 2006·Cancer Research·Elaine Y LinJeffrey W Pollard
Jan 11, 2007·Cancer Research·Vanessa C Gray-SchopferRichard Marais

❮ Previous
Next ❯

Citations

Nov 28, 2012·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·David M RichardsMarkus Feuerer
Aug 24, 2010·Oncogene·R M MelilloG Marone
Aug 15, 2012·Proceedings of the National Academy of Sciences of the United States of America·Joana Pinto CoutoJacqueline F Bromberg
Aug 9, 2012·Thyroid : Official Journal of the American Thyroid Association·Wei QingGuang Ning
Apr 12, 2011·Thyroid : Official Journal of the American Thyroid Association·Matthew D Ringel
Jan 16, 2013·Thyroid : Official Journal of the American Thyroid Association·Jena D French
Jul 9, 2009·Current Opinion in Endocrinology, Diabetes, and Obesity·Matthew D Ringel
Jan 26, 2012·BMC Cancer·Anne-Katrine BondeReto A Schwendener
Dec 20, 2011·Journal of Translational Medicine·Moniek Heusinkveld, Sjoerd H van der Burg
Mar 9, 2010·The Journal of Clinical Endocrinology and Metabolism·Jena D FrenchBryan R Haugen
Mar 3, 2011·PloS One·Francesca MiccichèItalia Bongarzone
Sep 17, 2013·Endocrine-related Cancer·John E Phay, Matthew D Ringel
Nov 7, 2008·Endocrine-related Cancer·Robert C SmallridgeJohn A Copland
Aug 26, 2014·PloS One·Aline HébrantCarine Maenhaut
Jul 24, 2014·BioMed Research International·Denise BuenrostroJulie A Sterling
Dec 4, 2013·Thyroid : Official Journal of the American Thyroid Association·Pierre Vanden BorreSareh Parangi
May 20, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Motokazu SugimotoHironori Kaneko
Dec 5, 2013·Endocrine-related Cancer·Lucas Leite CunhaLaura Sterian Ward
Oct 21, 2014·Scientifica·Laura Sterian Ward
Jun 24, 2014·Thyroid : Official Journal of the American Thyroid Association·Trevor E AngellAlan L Epstein
Dec 1, 2014·Surgical Pathology Clinics·Marc P PusztaszeriPeter M Sadow
Feb 16, 2016·The Journal of Clinical Investigation·Iñigo LandaJames A Fagin
Apr 26, 2014·Expert Opinion on Biological Therapy·Meghna TalekarMansoor Amiji
Nov 13, 2015·Endocrine-related Cancer·Sun Wook ChoYoung Joo Park
May 14, 2011·Molecular Aspects of Medicine·Mario Leonardo Squadrito, Michele De Palma
Mar 2, 2016·Nature Reviews. Clinical Oncology·Keith C Bible, Mabel Ryder
Nov 6, 2009·Annales de pathologie·Bernard Caillou, Gabriel Malouf
Oct 20, 2009·Molecular and Cellular Endocrinology·Valentina GuarinoRosa Marina Melillo
Dec 2, 2008·Best Practice & Research. Clinical Endocrinology & Metabolism·James A Fagin, Nicholas Mitsiades
Jul 8, 2010·The Prostate·Paul F LindholmAndré Kajdacsy-Balla

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Jeremy J W ChenPan-Chyr Yang
Nature
Alberto MantovaniFrances Balkwill
© 2022 Meta ULC. All rights reserved