Increased detection of latent tuberculosis by tuberculin skin test and booster phenomenon in early rheumatoid arthritis patients

Rheumatology International
L Pérez-BarbosaM A Garza-Elizondo

Abstract

The incidence of tuberculosis (TB) in rheumatoid arthritis (RA) patients is up to four times higher when compared to the general population, but their risk increases with the use of TNF-a drugs. Appropriate screening of latent tuberculosis infection (LTBI) and proper management of such cases substantially reduce the incidence of active TB. Tuberculin skin test (TST) is a widely used method for the detection of LTBI. The time of diagnosis of RA as well as the age of the patient might modify the TST performance. We did an observational, comparative study of RA patients with early and established disease, with the objective to know the prevalence of LTBI using the TST and booster test; an induration ≥5 mm was considered reactive. We evaluated 143 patients (83 [58 %] early RA patients). We found 31.3 and 21.7 % TST positivity in early and established RA patients, respectively. With the use of booster test, the positivity increased to 46.5 and 28.8 %, respectively (p = 0.048, OR 1.33, 95 % CI 1.01-1.75). In conclusion, we found that TST and booster test increased LTBI detection in early RA patients, which may suggest that time of RA diagnosis might affect cellular immunity and therefore the TST response.

References

Aug 14, 2003·Experimental Gerontology·Cornelia M WeyandJörg J Goronzy
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Allen KrautDaria McLean
Aug 1, 2006·American Journal of Infection Control·Kuddusi Cengiz, Ayşe Seker
Jun 2, 2009·Rheumatic Diseases Clinics of North America·Eduardo Acevedo-VásquezRocío Gamboa-Cárdenas
Jul 7, 2009·Rheumatology International·Maria Natalia TamboreneaAdrian Schijedman
Mar 30, 2010·Rheumatology International·Tulin CagatayAhmet Gul
Jul 27, 2010·Rheumatology International·Muhammad HaroonJoe Devlin
Sep 13, 2011·Médecine et maladies infectieuses·N MrozekH Laurichesse
Apr 8, 2014·Interdisciplinary Perspectives on Infectious Diseases·Shweta AgarwalRagini Srivastava

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Citations

Jul 21, 2015·Autoimmunity Reviews·Aaron Lerner, Torsten Matthias
Sep 8, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Cândida AbreuFernando Magro
Feb 28, 2019·International Journal of Rheumatic Diseases·Chak Sing LauSwan Sim Yeap
May 8, 2020·Journal of Immunology Research·Mariana HerreraZulma Vanessa Rueda
Mar 23, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Christianne BourlonAlfredo Ponce-de-León
Jun 2, 2021·BMC Infectious Diseases·Erick Antonio Osorio-LópezAlexandra Martin-Onraet

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