Increased Dickkopf-1 in Recent-onset Rheumatoid Arthritis is a New Biomarker of Structural Severity. Data from the ESPOIR Cohort

Scientific Reports
Raphaèle SerorCorinne Miceli-Richard

Abstract

Rheumatoid arthritis (RA) is the most common chronic inflammatory rheumatic condition over the world. RA is potentially disabling because chronic inflammation of the joints leads to joint destruction. To date, the best predictor of radiographic progression for patients with early RA is the presence of radiographic erosions at baseline, but a limited number of predictive biomarkers of structural progression are currently used in daily practice. Here, we investigated Dickkopf-1 (DKK-1) and sclerostin (SOST) serum levels in patients with recent inflammatory arthritis from the ESPOIR cohort. This cohort is a prospective, multicenter French cohort of 813 patients with early arthritis. We observed that mean baseline DKK-1 level was higher among RA patients with than without radiological progression within the first 2 years of evolution. DKK-1 level was still associated with radiographic progression in a model including other main predictors of severity (erosions at baseline, and anti-CCP antibody positivity). This study demonstrates that increased DKK-1 level at baseline predicted structural progression after 2-year follow-up and suggests that DKK-1 might be a new structural biomarker for early RA.

References

Feb 1, 1980·Arthritis and Rheumatism·J F FriesH R Holman
Nov 13, 2001·Developmental Cell·M MukhopadhyayH Westphal
Jul 13, 2002·American Journal of Medical Genetics·Karen Staehling-HamptonMary E Brunkow
Apr 16, 2003·Annals of the Rheumatic Diseases·J VencovskýS Růzicková
Jun 18, 2003·Annals of the Rheumatic Diseases·E LindqvistK Eberhardt
Nov 25, 2003·The EMBO Journal·David G WinklerJohn A Latham
Dec 26, 2003·The New England Journal of Medicine·Erming TianJohn D Shaughnessy
Oct 2, 2004·Annals of the Rheumatic Diseases·E LindqvistT Saxne
Jun 7, 2006·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Frederic MorvanGeorges Rawadi
Jan 24, 2007·Nature Medicine·Danielle DiarraGeorg Schett
Feb 19, 2008·Bone·Lynda F Bonewald, Mark L Johnson
Aug 9, 2008·Blood·Joseph J PinzoneJohn D Shaughnessy
Dec 30, 2009·Arthritis and Rheumatism·Dimitrios DaoussisAndrew P Andonopoulos
Aug 20, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ulrike I MödderSundeep Khosla
Aug 4, 2011·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Mohammed-Salleh M ArdawiMohammed H Qari
Oct 9, 2012·Annals of the Rheumatic Diseases·Diederik P C de RooyAnnette H M van der Helm-van Mil
May 15, 2013·Annals of the Rheumatic Diseases·Xiao-Xiang ChenAline Bozec
Jan 3, 2014·The New England Journal of Medicine·Michael R McClungHenry G Bone
Mar 26, 2015·Annals of the Rheumatic Diseases·Corinne Miceli-RichardLindsey A Criswell

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Citations

May 12, 2016·Clinical Reviews in Allergy & Immunology·Sofia Carvalho Barreira, João Eurico Fonseca
Aug 28, 2015·PloS One·Gaetane NocturneCorinne Miceli-Richard
Apr 19, 2017·Clinical and Experimental Immunology·C WehmeyerA J Naylor
Sep 17, 2016·Journal of Cellular Physiology·Guillaume CourbonHubert Marotte
Jul 12, 2018·Clinical Rheumatology·Giovanni OrsoliniOmbretta Viapiana
Aug 6, 2017·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·L Heinlen, M B Humphrey
Apr 26, 2020·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Alex Dario Cardona-RincónConsuelo Romero-Sánchez
Nov 11, 2019·International Journal of Molecular Sciences·Daniela CiciFrancesco P Cantatore
Aug 10, 2019·International Journal of Molecular Sciences·Josep Nácher-JuanMaría Luisa Ferrándiz
Jul 17, 2021·Chinese Medical Journal·Yukchiu ChungXue-Wu Zhang

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Methods Mentioned

BETA
transgenic
ESR
ELISA

Clinical Trials Mentioned

NCT01831648

Software Mentioned

SAS

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