Increased DNA Damage is Related to Maternal Blood Glucose Levels in the Offspring of Women With Diabetes and Mild Gestational Hyperglycemia

Reproductive Sciences
Rafael Bottaro GelaletiMarilza V C Rudge

Abstract

This study aimed at correlating maternal blood glucose levels with DNA damage levels in the offspring of women with diabetes or mild gestational hyperglycemia (MGH). Based on oral glucose tolerance test results and glycemic profiles, 56 pregnant women were allocated into 3 groups: nondiabetes, MGH, and diabetes. The offspring of these women (56 infants) were also evaluated. Maternal peripheral blood and umbilical cord blood samples were collected and processed for biochemical and DNA damage analysis by the comet assay. A positive correlation between maternal blood glucose mean and increased offspring DNA damage levels was observed. Hyperglycemia played a role in offspring DNA damage, but other diabetes-induced complications were also involved. Increased maternal blood glucose levels can lead to increased offspring DNA damage levels. Therefore, the monitoring, control, and treatment of pregnant women with diabetes and MGH are highly important to ensure a risk-free pregnancy and healthy infants.

References

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Citations

Jul 6, 2016·Archives of Toxicology·M GleiW Schlörmann
Jun 22, 2017·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·K Dulasi DurgaParkash Chand
May 11, 2018·Current Diabetes Reports·Linda A Barbour, Teri L Hernandez
Apr 11, 2018·Clinical Nursing Research·Chich-Hsiu HungMei-Chuan Huang
Jan 25, 2019·Journal of Perinatal Medicine·María F Castilla-PeonFausto Moisés Coronel Cruz
Jun 4, 2019·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Marilza Vieira Cunha RudgeUNKNOWN Perinatal Diabetes Research Group

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Methods Mentioned

BETA
electrophoresis
Assay
SGA

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