Increased dopamine availability magnifies nicotine effects on cognitive control: A pilot study.

Journal of Psychopharmacology
Stefan AhrensChristiane M Thiel

Abstract

The ability to adapt to new task demands flexibly and to stabilise performance in the presence of distractors is termed cognitive control and is mediated by dopaminergic and cholinergic neurotransmission. We aimed to test the hypothesis that the effect of the cholinergic agonist nicotine on cognitive control depends on baseline dopamine levels. Thirty-eight healthy non-smokers (16 males; Mage=24.05 years) performed a cognitive control task including distractor and switch trials twice. Subjects were split into two parallel groups. One group received 2 g of L-tyrosine two hours prior to testing to manipulate dopamine availability experimentally, while the other group received placebo on both days. One hour later, both groups received in a within-subject design: on one day, a 7 mg nicotine patch; on the other day, a matched placebo. Response time costs for distractor and switch trials served as measures of cognitive stability and flexibility. Nicotinic modulation reduced response time costs in switch trials and increased costs in distractor trials (nicotine×condition, p=0.027) with a trend-wise interaction between nicotine, L-tyrosine and trial type (nicotine×L-tyrosine×condition, p=0.068), which was due to stronger nicotine effec...Continue Reading

References

Jun 27, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·A Carlsson, M Lindqvist
Jul 16, 1979·Life Sciences·B S GlaeserR J Wurtman
May 1, 1989·Journal of Neurochemistry·M J DuringR J Wurtman
Jan 1, 1984·Clinical Neuropharmacology·J G Nutt, J H Fellman
Nov 14, 1997·Journal of Neurophysiology·M WatanabeK Hikosaka
Nov 13, 1998·The American Journal of Psychiatry·G W DalackJ H Meador-Woodruff
Nov 10, 2001·Brain : a Journal of Neurology·R CoolsT W Robbins
Jul 26, 2003·NeuroImage·Veena KumariTonmoy Sharma
Feb 7, 2004·Science·Min WangPatricia S Goldman-Rakic
Feb 26, 2004·Journal of Experimental Psychology. Learning, Memory, and Cognition·Gesine Dreisbach, Thomas Goschke
Mar 17, 2004·Current Opinion in Pharmacology·Paul A NewhouseAbhay Singh
Jun 21, 2005·Neuroscience and Biobehavioral Reviews·Veena Kumari, Peggy Postma
Aug 9, 2005·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·David G GilbertJodi I Huggenvik
Dec 22, 2005·Psychology of Addictive Behaviors : Journal of the Society of Psychologists in Addictive Behaviors·Bethea A KleykampThomas Eissenberg
May 22, 2007·The Journal of Nutrition·John D Fernstrom, Madelyn H Fernstrom
Jun 26, 2007·Physiology & Behavior·Caroline R MahoneyHarris R Lieberman
Nov 21, 2007·Pharmacology, Biochemistry, and Behavior·Alexandra S Potter, Paul A Newhouse
Jun 16, 2009·Biochemical Pharmacology·Phil D Livingstone, Susan Wonnacott
Oct 14, 2009·Proceedings of the National Academy of Sciences of the United States of America·Lea K KrugelHauke R Heekeren
Apr 24, 2010·Psychopharmacology·Stephen J HeishmanEdward G Singleton
Oct 22, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christine StelzelChristian J Fiebach
Dec 24, 2010·Archives of Biochemistry and Biophysics·S Colette DaubnerShanzhi Wang
Feb 2, 2011·Pharmacology, Biochemistry, and Behavior·J NesicA Jackson
May 3, 2011·Biological Psychiatry·Roshan Cools, Mark D'Esposito
Jul 11, 2012·Neuropharmacology·Claire Allison, Mohammed Shoaib
Jul 31, 2012·Neurochemistry International·Zachary BrodnikGeorge E Jaskiw
Aug 22, 2012·Journal of Cognitive Neuroscience·Diana J N ArmbrusterChristian J Fiebach
Jan 1, 2013·Biological Psychiatry·Gregory R Samanez-LarkinDavid H Zald
May 1, 2013·Biochemical Pharmacology·T L Wallace, D Bertrand
May 11, 2013·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Christine StelzelMark D'Esposito
Nov 10, 2013·Frontiers in Neuroscience·Marianne KlankerDamiaan Denys
Jan 1, 2014·Frontiers in Behavioral Neuroscience·Lorenza S ColzatoBernhard Hommel

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