Increased dopamine release from rat striatal slices by inhibitors of GABA-aminotransferase

European Journal of Pharmacology
J C Stoof, A H Mulder

Abstract

The effects were examined of two inhibitors of GABA-aminotransferase, amino-oxyacetic acid (AOAA) and RMI-71645-16, on depolarization-induced (30 mM K+) dopamine (DA) release from rat striatal slices. When added to the medium, these drugs increased the release of radiolabeled DA, either accumulated by high-affinity uptake or synthesized from 14C-tyrosine. AOAA did not modify the release of 14C-acetylcholine from striatal slices or 3H-noradrenaline from cortical slices. Moreover, 3H-DA release from substantia nigra was not affected. The data suggest the possibility that the effects of GABA-T inhibitors on striatal DA release are mediated by intrinsic GABA-ergic neurons.

Citations

Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B BauerL Aberg
Jul 15, 1979·European Journal of Pharmacology·J C StoofA H Mulder
Oct 1, 1979·Neuropharmacology·R M Di GiorgioG Nistico
Mar 1, 1980·Journal of Neurochemistry·G L CollingridgeP Tongroach
Jun 1, 1978·British Journal of Pharmacology·A Gibson, M Samini

Related Concepts

4-Aminobutyrate aminotransferase
Aminooxyacetate
Transaminases
Metazoa
Lentiform Nucleus Structure
Intropin
Gammalon
Substantia Nigra Structure
Rats, Laboratory
In Vitro [Publication Type]

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