Increased dopamine release from rat striatal slices by inhibitors of GABA-aminotransferase

European Journal of Pharmacology
J C Stoof, A H Mulder


The effects were examined of two inhibitors of GABA-aminotransferase, amino-oxyacetic acid (AOAA) and RMI-71645-16, on depolarization-induced (30 mM K+) dopamine (DA) release from rat striatal slices. When added to the medium, these drugs increased the release of radiolabeled DA, either accumulated by high-affinity uptake or synthesized from 14C-tyrosine. AOAA did not modify the release of 14C-acetylcholine from striatal slices or 3H-noradrenaline from cortical slices. Moreover, 3H-DA release from substantia nigra was not affected. The data suggest the possibility that the effects of GABA-T inhibitors on striatal DA release are mediated by intrinsic GABA-ergic neurons.


Jan 1, 1980·Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie. Albrecht Von Graefe's Archive for Clinical and Experimental Ophthalmology·B BauerL Aberg
Jul 15, 1979·European Journal of Pharmacology·J C StoofA H Mulder
Oct 1, 1979·Neuropharmacology·R M Di GiorgioG Nistico
Mar 1, 1980·Journal of Neurochemistry·G L CollingridgeP Tongroach
Jun 1, 1978·British Journal of Pharmacology·A Gibson, M Samini

Related Concepts

4-Aminobutyrate aminotransferase
Lentiform Nucleus Structure
Substantia Nigra Structure
Rats, Laboratory
In Vitro [Publication Type]

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