Increased dopaminergic activity in socially isolated rats: an electrophysiological study

Neuroscience Letters
Katrine FabriciusFlorence Sotty

Abstract

The development of animal models mimicking symptoms associated with schizophrenia has been a critical step in understanding the neurobiological mechanisms underlying the disease. Long-term social isolation from weaning in rodents, a model based on the neurodevelopmental hypothesis of schizophrenia, has been suggested to mimic some of the deficits seen in schizophrenic patients. We confirm in the present study that socially isolated rats display an increase in both spontaneous and d-amphetamine-induced locomotor activity, as well as deficits in sensorimotor gating as assessed in a pre-pulse inhibition paradigm. In addition, in vivo electrophysiological studies revealed changes in dopaminergic cell firing activity in the ventral tegmental area of isolated rats when compared to group-housed controls. These alterations include an increase in the number of spontaneously active dopaminergic neurons, and a change of firing activity towards a more irregular and bursting firing pattern. Taken together, our findings suggest that the behavioral phenotype induced by social isolation may be driven by an overactive dopamine system.

References

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Citations

Jan 5, 2011·Psychopharmacology·Katrine FabriciusBjörn Steiniger-Brach
Dec 16, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Salvatore LeccaMarco Pistis
Nov 28, 2012·Journal of Psychiatry & Neuroscience : JPN·André L Takatsu-ColemanRoberto Frussa-Filho
Oct 5, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Katrine FabriciusGitta Wörtwein
Jun 27, 2015·Neuropharmacology·Claudia SaghedduMarco Pistis
Jan 9, 2013·The European Journal of Neuroscience·Jordan T YorgasonSara R Jones
Nov 16, 2010·Behavioural Brain Research·A C IssyE A Del Bel
May 8, 2016·Alcoholism, Clinical and Experimental Research·Tracy R ButlerJeffrey L Weiner
Jun 18, 2016·The American Journal of Drug and Alcohol Abuse·Enoch NgAlbert H C Wong
Oct 18, 2016·Genes, Brain, and Behavior·N W Gilpin, J L Weiner
Apr 26, 2019·The Journal of Experimental Biology·Nadejda TsvetkovAmro Zayed
Jun 1, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Carine LampertCarla Dalmaz
Aug 17, 2019·Frontiers in Behavioral Neuroscience·Tomek J Banasikowski, Emily R Hawken
Apr 1, 2011·British Journal of Pharmacology·C A JonesK C F Fone

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