Increased dopaminergic function in the thalamus is associated with excessive daytime sleepiness

Sleep Medicine
Tayyabah YousafMarios Politis

Abstract

Excessive daytime sleepiness (EDS) is a common disorder, which can manifest in isolation or in combination with other neurological or psychiatric disorders. We know relatively little about the mechanisms underlying the development of EDS and the clinical management of patients with EDS remains an unmet need. In this study, we hypothesised that thalamic dopaminergic function would be altered in subjects with EDS and we sought to investigate this by assessing [123I]FP-CIT Single Photon Emission Computed Tomography (SPECT) data, which is a molecular imaging marker of dopamine transporter (DAT). We performed a case-control study using people registered as healthy subjects in the Parkinson's Progression Markers Initiative database. We assessed and compared semi-quantified [123I]FP-CIT-SPECT in two groups of 21 healthy subjects with and without EDS, who were matched for age, gender, years of education and Rapid eyemovement (REM) sleep behaviour disorder (RBD) Questionnaire scores. Our findings show increased thalamic DAT binding in people with EDS compared to matched healthy subjects without EDS. Higher thalamic DAT binding also correlated with worse EDS scores. Our findings provide evidence that increased dopaminergic function in th...Continue Reading

Citations

Dec 25, 2019·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Sang-Won YooJoong-Seok Kim
May 7, 2019·Frontiers in Neurology·Amir Ashraf-GanjoueiMohammad Hadi Aarabi
Jun 6, 2018·International Journal of Molecular Sciences·Martina PfefferCharlotte von Gall
Feb 28, 2021·Parkinsonism & Related Disorders·Fei FengHuiFang Shang

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