Increased Doses Lead to Higher Drug Exposures of Levofloxacin for Treatment of Tuberculosis

Antimicrobial Agents and Chemotherapy
C A PeloquinC Robert Horsburgh

Abstract

Patients with multidrug-resistant tuberculosis in Peru and South Africa were randomized to a weight-banded nominal dose of 11, 14, 17, or 20 mg/kg/day levofloxacin (minimum, 750 mg) in combination with other second-line agents. A total of 101 patients were included in noncompartmental pharmacokinetic analyses. Respective median areas under the concentration-time curve from 0 to 24 h (AUC0-24) were 109.49, 97.86, 145.33, and 207.04 μg · h/ml. Median maximum plasma concentration (Cmax) were 11.90, 12.02, 14.86, and 19.17 μg/ml, respectively. Higher levofloxacin doses, up to 1,500 mg daily, resulted in higher exposures. (This study has been registered at ClinicalTrials.gov under identifier NCT01918397.).

References

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Dec 12, 2007·Antimicrobial Agents and Chemotherapy·Charles A PeloquinJohn L Johnson
May 23, 2014·Drugs·Abdullah Alsultan, Charles A Peloquin

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Citations

Feb 26, 2019·Antimicrobial Agents and Chemotherapy·Amyn A MalikCourtney M Yuen
Jan 19, 2019·The European Respiratory Journal·Samiksha GhimireJan-Willem C Alffenaar
Nov 16, 2019·American Journal of Respiratory and Critical Care Medicine·Payam NahidBarbara Seaworth
Jan 12, 2020·European Journal of Drug Metabolism and Pharmacokinetics·Kyle John Wilby, Farhat Naz Hussain
Oct 13, 2020·Expert Opinion on Drug Metabolism & Toxicology·Anne-Grete MärtsonCharles A Peloquin
Oct 23, 2020·The Journal of Antimicrobial Chemotherapy·Jan-Willem C AlffenaarDaan J Touw

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