Increased drinking after intra-striatal injection of the dopamine D2/D3 receptor agonist quinpirole in the rat.

Psychopharmacology
Davide AmatoAldo Badiani

Abstract

Dopamine D2 receptor hyperactivity has been implicated in the development of psychogenic polydipsia in schizophrenic patients. Repeated treatment with dopamine agonists, including the D2/D3 agonist quinpirole, has been shown to induce hyperdipsia in a number of animal models. Despite these observations, obtained with systemic administrations, little attempt has been made to investigate where in the brain dopamine agonists act to induce hyperdipsia. The present study investigates the effects of repeated intra-caudate infusions of quinpirole on the intake of water by rats tested under free-drinking conditions. Rats with bilateral cannulae placed into the anterior, central or posterior caudate received quinpirole microinfusions (1 μg/side) for five consecutive days in their home cage. Water intake was measured 15 and 60 min after the treatment. When injected in the central caudate, quinpirole increased water intake, and this effect progressively increased over sessions, indicating the development of sensitization. When injected in the posterior caudate, the dipsogenic effect of quinpirole was less intense and did not undergo sensitization. The infusion of quinpirole in the anterior caudate did not affect drinking. The present stud...Continue Reading

References

Dec 1, 1978·JAMA : the Journal of the American Medical Association·M RendellM Cuesta
Sep 1, 1975·The American Journal of Psychiatry·M A RaskindT G Christopher
Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L L Brown
Jun 1, 1988·The American Journal of Psychiatry·B P Illowsky, D G Kirch
Jan 1, 1988·Progress in Neuro-psychopharmacology & Biological Psychiatry·M Pisa
Oct 1, 1986·Physiology & Behavior·J P Kroon, A L Riley
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·U Ungerstedt
Jan 1, 1966·Journal of the Experimental Analysis of Behavior·J L Falk
May 1, 1981·British Medical Bulletin·B J Rolls, E T Rolls
Nov 1, 1994·The American Journal of Psychiatry·C VergheseG M Simpson
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·J D SalamoneS Rogers
Sep 12, 2002·Schizophrenia Research·Jose de LeonAmy McGrory
Dec 20, 2003·Annals of the New York Academy of Sciences·Susan R SesackAline Pinto
Aug 25, 2004·Behavioural Brain Research·Daniel D Kurylo
Apr 27, 2005·The International Journal of Neuropsychopharmacology·Chima MatsumotoJun Nakamura
May 9, 2006·Behavioural Brain Research·Davide AmatoPaolo Nencini
Mar 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Giovanna PaoloneAldo Badiani

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Citations

Jun 19, 2013·Nature Medicine·Erich GulbinsJohannes Kornhuber
Oct 21, 2014·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H KarasawaL Wang
Jan 16, 2014·Parkinsonism & Related Disorders·Roberto CiliaGianni Pezzoli
Feb 6, 2018·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mehmet Emin CeylanAlper Evrensel

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