PMID: 9421091Jul 1, 1997Paper

Increased E-cadherin expression in ovarian surface epithelium: an early step in metaplasia and dysplasia?

International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists
Sarah Maines-Bandiera, N Auersperg

Abstract

Ovarian surface epithelium (OSE), the source of common epithelial carcinomas, is a simple mesothelium that during carcinogenesis acquires complex epithelial characteristics normally found in tubal, endometrial, and endocervical epithelia. These characteristics include the intercellular adhesive molecule E-cadherin. We examined cryostat sections of 12 normal ovaries by immunofluorescence and immunocytochemistry to determine whether E-cadherin is a component of normal OSE that is retained in ovarian cancers or whether it, like many other epithelial characteristics, is acquired in the course of metaplasia and neoplastic progression. E-cadherin expression by OSE varied with its location within the ovary and with cell shape. It was present inconsistently on the ovarian surface but was increased in surface invaginations and particularly in epithelial inclusion cysts. Independent of location, E-cadherin was most prominent in columnar, variable in cuboidal, and absent in flat OSE. This relationship to cell morphology accounts for the increased E-cadherin expression in inclusion cysts, which are sites of frequent metaplastic and dysplastic changes. These results suggest that the morphologic variation of OSE reflects differences in E-cad...Continue Reading

Citations

Nov 20, 1997·Journal of Cellular Physiology·N AuerspergH G Dyck
Jan 23, 2002·Molecular Reproduction and Development·Naomi H MachellRiaz Farookhi
Oct 27, 2009·International Journal of Clinical Oncology·Masaki MandaiIkuo Konishi
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