PMID: 9181238Jun 1, 1997Paper

Increased endothelial cell retraction and tumor cell invasion by soluble factors derived from pancreatic cancer cells

Annals of Surgical Oncology
S NakamoriH Akedo

Abstract

Tumor cells induce endothelial cell retraction before invasion. In pancreatic cancer cells, the factors affecting endothelial cell retraction are not well-understood. The activities of the endothelial cell retraction in conditioned media (CM) derived from three human pancreatic cancer cell lines, PSN-1, MiaPaca-2, and Capan-1, were measured for the amount of intercellular junctional transport of FITC dextran through an endothelial cell monolayer in a transwell cell culture system. The CM derived from the three pancreatic cancer cells induced endothelial cell retraction. The endothelial cell retraction activity in the CM from PSN-1 cells was significantly higher than those from MiaPaca-2 and Capan-1 cells. The CM from PSN-1 cells enhanced both the adhesion and the invasion of MiaPaca-2 and Capan-1 cells. The factors with endothelial cell retraction activity in the CM from PSN-1 cells were characterized as heat-stable, trypsin-sensitive glycoproteins ranging from 10,000 to 50,000 in molecular weight, and were found both in heparin-bound and unbound fractions. PSN-1 cells produced and secreted at least two factors inducing the endothelial cell retraction. The factors could play an important role in the establishment of invasion an...Continue Reading

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Citations

Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Olaf R F MookCornelis J F Van Noorden
Feb 24, 2015·Brain Tumor Pathology·Manabu OnishiIsao Date
Jun 24, 2008·Endothelium : Journal of Endothelial Cell Research·Xi-Qiao WangDa-Zhong Xu
Oct 18, 2013·American Journal of Physiology. Cell Physiology·Kimberly M Stroka, Konstantinos Konstantopoulos

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