Increased Endothelial Progenitor Cell Number in Early Stage of Endometrial Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Maria PaprockaJerzy Heimrath

Abstract

It is generally believed that circulating endothelial cells (CECs) and endothelial progenitor cells (EPCs) reflect the state of the endothelium, its injury and/or repair possibilities. In different types of cancers, increased numbers of CECs and EPCs were found, suggesting their participation in cancer angiogenesis. The objective of this study was to determine whether, in the blood circulation of women with early endometrial cancer, CEC and EPC levels differ from those of healthy women of similar age. For CEC number evaluation, samples of peripheral blood cells of women with endometrial carcinoma and control subjects were labeled with anti-CD31 and anti-CD45 antibodies; for EPCs, with anti-VEGFR2 (vascular-endothelium growth factor receptor 2)/KDR and anti-CD34 antibodies. The CEC and EPC cells were then quantified by flow cytometry. Endothelial progenitor cell numbers (CD34, VEGFR2/KDR) in the peripheral blood of women with endometrial carcinoma were significantly augmented as compared with those of control healthy women and CEC numbers (CD31, CD45) were similar in both groups. Cancer patients were divided according to the grading into G1 and G2 groups and according to the stage into International Federation of Gynecology and ...Continue Reading

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Citations

Feb 22, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Aug 9, 2018·International Journal of Molecular Sciences·Laura Muinelo-RomayMiguel Abal
Mar 1, 2019·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Apr 10, 2019·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Magdalena WawrzyńskaJ Gerard Wall
Jan 13, 2021·International Journal of Molecular Sciences·Aleksandra MajewskaClaudine Kieda

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